7cat

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[[Image:7cat.gif|left|200px]]
[[Image:7cat.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 7cat |SIZE=350|CAPTION= <scene name='initialview01'>7cat</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_7cat", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_7cat| PDB=7cat | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=7cat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cat OCA], [http://www.ebi.ac.uk/pdbsum/7cat PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=7cat RCSB]</span>
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}}
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'''THE NADPH BINDING SITE ON BEEF LIVER CATALASE'''
'''THE NADPH BINDING SITE ON BEEF LIVER CATALASE'''
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==About this Structure==
==About this Structure==
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7CAT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CAT OCA].
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7CAT is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CAT OCA].
==Reference==
==Reference==
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[[Category: Sicignano, A.]]
[[Category: Sicignano, A.]]
[[Category: Tanaka, N.]]
[[Category: Tanaka, N.]]
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[[Category: oxidoreductase (h2o2 acceptor)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:44:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:43:52 2008''
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Revision as of 19:44, 4 May 2008

Image:7cat.gif

Template:STRUCTURE 7cat

THE NADPH BINDING SITE ON BEEF LIVER CATALASE


Overview

Beef liver and human erythrocyte catalases (EC 1.11.1.6) bind NADP tenaciously [Kirkman, H. N. & Gaetani, G. F. (1984) Proc. Natl. Acad. Sci. USA 81, 4343-4348]. The position of NADP on beef liver catalase corresponds to the carboxyl-terminal polypeptide hinge in Penicillium vitale fungal catalase, which connects the common catalase structure to the additional flavodoxin-like domain. In contrast to nearly all other known structures of protein-bound NADP, NAD, and FAD, the NADP molecule of beef liver catalase is folded into a right-handed helix and bound, in part, in the vicinity of the carboxyl end of two alpha-helices. A water molecule (W7) occupies a pseudosubstrate site close to the C4 position of the nicotinamide and is hydrogen bonded to His-304. Although the NADP and heme groups approach each other to within 13.7 A, there is no direct interaction. The function of the NADP remains a mystery.

About this Structure

7CAT is a Single protein structure. Full crystallographic information is available from OCA.

Reference

The NADPH binding site on beef liver catalase., Fita I, Rossmann MG, Proc Natl Acad Sci U S A. 1985 Mar;82(6):1604-8. PMID:3856839 Page seeded by OCA on Sun May 4 22:44:11 2008

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OCA

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