6a93

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6a93 is ON HOLD until Paper Publication
+
==Crystal structure of 5-HT2AR in complex with risperidone==
-
 
+
<StructureSection load='6a93' size='340' side='right' caption='[[6a93]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-
Authors: Kimura, T.K., Shimamura, T.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6a93]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A93 FirstGlance]. <br>
-
Description: Crystal structure of 5-HT2AR in complex with risperidone
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=8NU:3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one'>8NU</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a93 OCA], [http://pdbe.org/6a93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a93 RCSB], [http://www.ebi.ac.uk/pdbsum/6a93 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a93 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/5HT2A_HUMAN 5HT2A_HUMAN]] G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores (PubMed:18703043, PubMed:28129538). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.<ref>PMID:1330647</ref> <ref>PMID:18297054</ref> <ref>PMID:18703043</ref> <ref>PMID:19057895</ref> <ref>PMID:21645528</ref> <ref>PMID:22300836</ref> <ref>PMID:28129538</ref> (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.<ref>PMID:24089568</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Aoki, J]]
 +
[[Category: Arakawa, T]]
 +
[[Category: Asada, H]]
 +
[[Category: Hirata, K]]
 +
[[Category: Im, D]]
 +
[[Category: Inoue, A]]
 +
[[Category: Iwata, S]]
 +
[[Category: Kadji, F M.N]]
 +
[[Category: Kimura, T K]]
 +
[[Category: Mori, C]]
 +
[[Category: Nomura, N]]
 +
[[Category: Nomura, Y]]
[[Category: Shimamura, T]]
[[Category: Shimamura, T]]
-
[[Category: Kimura, T.K]]
+
[[Category: Membrane protein]]

Revision as of 09:25, 13 February 2019

Crystal structure of 5-HT2AR in complex with risperidone

6a93, resolution 3.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6a93"
Personal tools