6a94

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'''Unreleased structure'''
 
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The entry 6a94 is ON HOLD until Paper Publication
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==Crystal structure of 5-HT2AR in complex with zotepine==
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<StructureSection load='6a94' size='340' side='right' caption='[[6a94]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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Authors: Kimura, T.K., Shimamura, T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6a94]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A94 FirstGlance]. <br>
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Description: Crystal structure of 5-HT2AR in complex with zotepine
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=A6L:2,3-dihydroxypropyl+(9Z)-octadec-9-enoate'>A6L</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=ZOT:2-(3-chloranylbenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethyl-ethanamine'>ZOT</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a94 OCA], [http://pdbe.org/6a94 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a94 RCSB], [http://www.ebi.ac.uk/pdbsum/6a94 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a94 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/5HT2A_HUMAN 5HT2A_HUMAN]] G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores (PubMed:18703043, PubMed:28129538). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.<ref>PMID:1330647</ref> <ref>PMID:18297054</ref> <ref>PMID:18703043</ref> <ref>PMID:19057895</ref> <ref>PMID:21645528</ref> <ref>PMID:22300836</ref> <ref>PMID:28129538</ref> (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.<ref>PMID:24089568</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Aoki, J]]
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[[Category: Arakawa, T]]
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[[Category: Asada, H]]
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[[Category: Hirata, K]]
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[[Category: Im, D]]
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[[Category: Inoue, A]]
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[[Category: Iwata, S]]
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[[Category: Kadji, F M.N]]
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[[Category: Kimura, T K]]
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[[Category: Mori, C]]
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[[Category: Nomura, N]]
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[[Category: Nomura, Y]]
[[Category: Shimamura, T]]
[[Category: Shimamura, T]]
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[[Category: Kimura, T.K]]
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[[Category: Membrane protein]]
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[[Category: Receptor]]

Revision as of 09:25, 13 February 2019

Crystal structure of 5-HT2AR in complex with zotepine

6a94, resolution 2.90Å

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