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6j0x

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'''Unreleased structure'''
 
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The entry 6j0x is ON HOLD until Paper Publication
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==Crystal Structure of Yeast Rtt107 and Mms22==
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<StructureSection load='6j0x' size='340' side='right'caption='[[6j0x]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
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Authors: Wan, B., Wu, J., Lei, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6j0x]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J0X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J0X FirstGlance]. <br>
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Description: Crystal Structure of Yeast Rtt107 and Mms22
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6j0w|6j0w]]</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j0x OCA], [http://pdbe.org/6j0x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j0x RCSB], [http://www.ebi.ac.uk/pdbsum/6j0x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j0x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/RT107_YEAST RT107_YEAST]] Required for resumption of chromosome replication after DNA damage, specifically in S phase. Is recruited to chromatin in the presence of RTT109 and RTT101 in response to stalled replication forks and acts as a scaffold during DNA repair.<ref>PMID:14988729</ref> <ref>PMID:17978089</ref> [[http://www.uniprot.org/uniprot/MMS22_YEAST MMS22_YEAST]] Substrate targeting component of a cullin-RING-based E3 ubiquitin-protein ligase complex RTT101(MMS1-MMS22). RTT101(MMS1-MMS22) promotes fork progression through damaged DNA or natural pause sites by stabilizing replication proteins like the replication fork-pausing complex (FPC) and leading-strand polymerase at stalled replication forks. RTT101(MMS1-MMS22) ubiquitinates the acetylated histones H3K56ac-H4 at lysine residues H3K121, H3K122 and H3K125. Ubiquitination is required for efficient histone deposition during replication-coupled nucleosome assembly, probably by facilitating the transfer of H3-H4 from ASF1 to other chaperones involved in histone deposition.<ref>PMID:12482937</ref> <ref>PMID:12694535</ref> <ref>PMID:15718301</ref> <ref>PMID:16024805</ref> <ref>PMID:18321796</ref> <ref>PMID:18704118</ref> <ref>PMID:21593207</ref> <ref>PMID:24209620</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Lei, M]]
[[Category: Wan, B]]
[[Category: Wan, B]]
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[[Category: Lei, M]]
 
[[Category: Wu, J]]
[[Category: Wu, J]]
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[[Category: Brct domain]]
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[[Category: Mitosis]]
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[[Category: Protein binding]]
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[[Category: Protein interaction]]

Revision as of 16:33, 14 August 2019

Crystal Structure of Yeast Rtt107 and Mms22

PDB ID 6j0x

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