8psh

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[[Image:8psh.gif|left|200px]]
[[Image:8psh.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 8psh |SIZE=350|CAPTION= <scene name='initialview01'>8psh</scene>
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The line below this paragraph, containing "STRUCTURE_8psh", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=AS:2-DEOXY-ADENOSINE+-5&#39;-THIO-MONOPHOSPHATE'>AS</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=GS:GUANOSINE-5&#39;-THIO-MONOPHOSPHATE'>GS</scene>, <scene name='pdbligand=PST:THYMIDINE-5&#39;-THIOPHOSPHATE'>PST</scene>, <scene name='pdbligand=SC:2-DEOXY-CYTIDINE-5&#39;-THIOPHOSPHORATE'>SC</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_8psh| PDB=8psh | SCENE= }}
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|RELATEDENTRY=[[8drh|8DRH]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=8psh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8psh OCA], [http://www.ebi.ac.uk/pdbsum/8psh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=8psh RCSB]</span>
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}}
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'''HIGH RESOLUTION NMR STRUCTURE OF THE STEREOREGULAR (ALL-RP)-PHOSPHOROTHIOATE-DNA/RNA HYBRID D (G*PS*C*PS*G*PS*T*PS*C*PS*A*PS*G*PS*G)R(CCUGACGC), MINIMIZED AVERAGE STRUCTURE'''
'''HIGH RESOLUTION NMR STRUCTURE OF THE STEREOREGULAR (ALL-RP)-PHOSPHOROTHIOATE-DNA/RNA HYBRID D (G*PS*C*PS*G*PS*T*PS*C*PS*A*PS*G*PS*G)R(CCUGACGC), MINIMIZED AVERAGE STRUCTURE'''
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==About this Structure==
==About this Structure==
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8PSH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PSH OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PSH OCA].
==Reference==
==Reference==
Structure of a stereoregular phosphorothioate DNA/RNA duplex., Bachelin M, Hessler G, Kurz G, Hacia JG, Dervan PB, Kessler H, Nat Struct Biol. 1998 Apr;5(4):271-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9546216 9546216]
Structure of a stereoregular phosphorothioate DNA/RNA duplex., Bachelin M, Hessler G, Kurz G, Hacia JG, Dervan PB, Kessler H, Nat Struct Biol. 1998 Apr;5(4):271-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9546216 9546216]
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[[Category: Protein complex]]
 
[[Category: Bachelin, M.]]
[[Category: Bachelin, M.]]
[[Category: Dervan, P B.]]
[[Category: Dervan, P B.]]
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[[Category: Kessler, H.]]
[[Category: Kessler, H.]]
[[Category: Kurz, G.]]
[[Category: Kurz, G.]]
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[[Category: antisense]]
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[[Category: Antisense]]
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[[Category: dna/rna hybrid]]
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[[Category: Dna/rna hybrid]]
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[[Category: oligonucleotide]]
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[[Category: Oligonucleotide]]
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[[Category: phosphorothioate]]
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[[Category: Phosphorothioate]]
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[[Category: thionucleotide]]
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[[Category: Thionucleotide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:51:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:45:43 2008''
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Revision as of 19:51, 4 May 2008

Image:8psh.gif

Template:STRUCTURE 8psh

HIGH RESOLUTION NMR STRUCTURE OF THE STEREOREGULAR (ALL-RP)-PHOSPHOROTHIOATE-DNA/RNA HYBRID D (G*PS*C*PS*G*PS*T*PS*C*PS*A*PS*G*PS*G)R(CCUGACGC), MINIMIZED AVERAGE STRUCTURE


Overview

In this work, we present the first NMR solution structure of a DNA/RNA hybrid containing stereoregular Rp-phosphorothioate modifications of all DNA backbone linkages. The complex of the enzymatically synthesized phosphorothioate DNA octamer (all-Rp)-d(GCGTCAGG) and its complementary RNA r(CCUGACGC) was found to adopt an overall conformation within the A-form family. Most helical parameters and the sugar puckers of the DNA strand assume values intermediate between A- and B-form. The close structural similarity with the unmodified DNA/RNA hybrid of the same sequence may explain why both the natural and the sulfur-substituted complex can be recognized and digested by ribonuclease H.

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of a stereoregular phosphorothioate DNA/RNA duplex., Bachelin M, Hessler G, Kurz G, Hacia JG, Dervan PB, Kessler H, Nat Struct Biol. 1998 Apr;5(4):271-6. PMID:9546216 Page seeded by OCA on Sun May 4 22:51:35 2008

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