6qfi

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'''Unreleased structure'''
 
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The entry 6qfi is ON HOLD until Paper Publication
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==Structure of human Mcl-1 in complex with BIM BH3 peptide==
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<StructureSection load='6qfi' size='340' side='right'caption='[[6qfi]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors: Dokurno, P., Murray, J., Davidson, J., Chen, I., Davis, B., Graham, C.J., Harris, R., Jordan, A.M., Matassova, N., Pedder, C., Ray, S., Roughley, S., Smith, J., Walmsley, C., Wang, Y., Whitehead, N., Williamson, D.S., Casara, P., Le Diguarher, T., Hickman, J., Stark, J., Kotschy, A., Geneste, O., Hubbard, R.E.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6qfi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QFI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QFI FirstGlance]. <br>
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Description: Structure of human Mcl-1 in complex with BIM BH3 peptide
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qfi OCA], [http://pdbe.org/6qfi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qfi RCSB], [http://www.ebi.ac.uk/pdbsum/6qfi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qfi ProSAT]</span></td></tr>
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[[Category: Pedder, C]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> [[http://www.uniprot.org/uniprot/B2L11_HUMAN B2L11_HUMAN]] Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.<ref>PMID:9430630</ref> <ref>PMID:11734221</ref> <ref>PMID:12019181</ref> <ref>PMID:11997495</ref> <ref>PMID:15147734</ref> <ref>PMID:15486195</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Casara, P]]
[[Category: Chen, I]]
[[Category: Chen, I]]
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[[Category: Williamson, D.S]]
 
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[[Category: Smith, J]]
 
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[[Category: Le Diguarher, T]]
 
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[[Category: Matassova, N]]
 
[[Category: Davidson, J]]
[[Category: Davidson, J]]
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[[Category: Wang, Y]]
 
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[[Category: Roughley, S]]
 
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[[Category: Walmsley, C]]
 
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[[Category: Graham, C.J]]
 
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[[Category: Hubbard, R.E]]
 
[[Category: Davis, B]]
[[Category: Davis, B]]
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[[Category: Diguarher, T Le]]
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[[Category: Dokurno, P]]
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[[Category: Geneste, O]]
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[[Category: Graham, C J]]
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[[Category: Harris, R]]
[[Category: Hickman, J]]
[[Category: Hickman, J]]
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[[Category: Hubbard, R E]]
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[[Category: Jordan, A M]]
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[[Category: Kotschy, A]]
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[[Category: Matassova, N]]
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[[Category: Murray, J]]
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[[Category: Pedder, C]]
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[[Category: Ray, S]]
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[[Category: Roughley, S]]
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[[Category: Smith, J]]
[[Category: Stark, J]]
[[Category: Stark, J]]
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[[Category: Walmsley, C]]
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[[Category: Wang, Y]]
[[Category: Whitehead, N]]
[[Category: Whitehead, N]]
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[[Category: Jordan, A.M]]
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[[Category: Williamson, D S]]
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[[Category: Harris, R]]
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[[Category: Apoptosis]]
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[[Category: Murray, J]]
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[[Category: Bcl2]]
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[[Category: Dokurno, P]]
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[[Category: Bim]]
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[[Category: Kotschy, A]]
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[[Category: Mcl1]]
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[[Category: Casara, P]]
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[[Category: Geneste, O]]
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[[Category: Ray, S]]
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Revision as of 05:45, 12 June 2019

Structure of human Mcl-1 in complex with BIM BH3 peptide

PDB ID 6qfi

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