This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6qfm
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human Mcl-1 in complex with PUMA BH3 peptide== | |
| - | + | <StructureSection load='6qfm' size='340' side='right'caption='[[6qfm]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6qfm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QFM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QFM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6qfi|6qfi]]</td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qfm OCA], [http://pdbe.org/6qfm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qfm RCSB], [http://www.ebi.ac.uk/pdbsum/6qfm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qfm ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> [[http://www.uniprot.org/uniprot/BBC3_HUMAN BBC3_HUMAN]] Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis.<ref>PMID:11463391</ref> <ref>PMID:23340338</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Casara, P]] | ||
[[Category: Chen, I]] | [[Category: Chen, I]] | ||
| - | [[Category: Williamson, D.S]] | ||
| - | [[Category: Smith, J]] | ||
| - | [[Category: Le Diguarher, T]] | ||
| - | [[Category: Matassova, N]] | ||
[[Category: Davidson, J]] | [[Category: Davidson, J]] | ||
| - | [[Category: Wang, Y]] | ||
| - | [[Category: Roughley, S]] | ||
| - | [[Category: Walmsley, C]] | ||
| - | [[Category: Graham, C.J]] | ||
| - | [[Category: Hubbard, R.E]] | ||
[[Category: Davis, B]] | [[Category: Davis, B]] | ||
| + | [[Category: Diguarher, T Le]] | ||
| + | [[Category: Dokurno, P]] | ||
| + | [[Category: Geneste, O]] | ||
| + | [[Category: Graham, C J]] | ||
| + | [[Category: Harris, R]] | ||
[[Category: Hickman, J]] | [[Category: Hickman, J]] | ||
| + | [[Category: Hubbard, R E]] | ||
| + | [[Category: Jordan, A M]] | ||
| + | [[Category: Kotschy, A]] | ||
| + | [[Category: Matassova, N]] | ||
| + | [[Category: Murray, J]] | ||
| + | [[Category: Pedder, C]] | ||
| + | [[Category: Ray, S]] | ||
| + | [[Category: Roughley, S]] | ||
| + | [[Category: Smith, J]] | ||
[[Category: Stark, J]] | [[Category: Stark, J]] | ||
| + | [[Category: Walmsley, C]] | ||
| + | [[Category: Wang, Y]] | ||
[[Category: Whitehead, N]] | [[Category: Whitehead, N]] | ||
| - | [[Category: | + | [[Category: Williamson, D S]] |
| - | [[Category: | + | [[Category: Apoptosis]] |
| - | [[Category: | + | [[Category: Bcl2]] |
| - | [[Category: | + | [[Category: Mcl1]] |
| - | [[Category: | + | [[Category: Puma]] |
| - | + | ||
| - | + | ||
| - | + | ||
Revision as of 05:45, 12 June 2019
Structure of human Mcl-1 in complex with PUMA BH3 peptide
| |||||||||||
Categories: Large Structures | Casara, P | Chen, I | Davidson, J | Davis, B | Diguarher, T Le | Dokurno, P | Geneste, O | Graham, C J | Harris, R | Hickman, J | Hubbard, R E | Jordan, A M | Kotschy, A | Matassova, N | Murray, J | Pedder, C | Ray, S | Roughley, S | Smith, J | Stark, J | Walmsley, C | Wang, Y | Whitehead, N | Williamson, D S | Apoptosis | Bcl2 | Mcl1 | Puma
