6qh4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human Methylmalonyl-CoA epimerase (MCEE) p.Arg143Cys variant== | |
| - | + | <StructureSection load='6qh4' size='340' side='right' caption='[[6qh4]], [[Resolution|resolution]] 1.92Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6qh4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QH4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QH4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_epimerase Methylmalonyl-CoA epimerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.99.1 5.1.99.1] </span></td></tr> |
| - | [[Category: Bailey, H | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qh4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qh4 OCA], [http://pdbe.org/6qh4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qh4 RCSB], [http://www.ebi.ac.uk/pdbsum/6qh4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qh4 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/MCEE_HUMAN MCEE_HUMAN]] Vitamin B12-unresponsive methylmalonic acidemia. Methylmalonyl-CoA epimerase deficiency (MCEED) [MIM:[http://omim.org/entry/251120 251120]]: Autosomal recessive inborn error of amino acid metabolism, involving valine, threonine, isoleucine and methionine. This organic aciduria may present in the neonatal period with life-threatening metabolic acidosis, hyperammonemia, feeding difficulties, pancytopenia and coma. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:16752391</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Methylmalonyl-CoA epimerase]] | ||
| + | [[Category: Bailey, H J]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Chaikuid, A]] | ||
| + | [[Category: Diaz-Saez, L]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Froese, D S]] | ||
[[Category: Kennedy, E]] | [[Category: Kennedy, E]] | ||
[[Category: Krysztofinska, E]] | [[Category: Krysztofinska, E]] | ||
| - | [[Category: | + | [[Category: Sorrell, F J]] |
| - | [[Category: | + | [[Category: Yue, W W]] |
| - | [[Category: | + | [[Category: Isomerase]] |
| - | [[Category: | + | [[Category: Methylmalonyl-coa epimerase]] |
| - | [[Category: | + | [[Category: Mitochondrial]] |
| - | + | ||
Revision as of 15:37, 27 February 2019
Crystal structure of human Methylmalonyl-CoA epimerase (MCEE) p.Arg143Cys variant
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