6qje

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "6qje" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6qje is ON HOLD
+
==Structure of human galactokinase 1 bound with 4-{[2-(Methylsulfonyl)-1H-imidazol-1-yl]methyl}-1,3-thiazole==
-
 
+
<StructureSection load='6qje' size='340' side='right' caption='[[6qje]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-
Authors: Mackinnon, S.R., Bezerra, G.A., Zhang, M., Foster, W., Krojer, T., Brandao-Neto, J., Douangamath, A., Arrowsmith, C., Edwards, A., Bountra, C., Brennan, P., Lai, K., Yue, W.W.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6qje]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QJE FirstGlance]. <br>
-
Description: Structure of human galactokinase 1 bound with 4-{[2-(Methylsulfonyl)-1H-imidazol-1-yl]methyl}-1,3-thiazole
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=HFK:2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1-cyclohexane]-5-one'>HFK</scene>, <scene name='pdbligand=J4Q:4-[(2-methylsulfonylimidazol-1-yl)methyl]-1,3-thiazole'>J4Q</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Galactokinase Galactokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.6 2.7.1.6] </span></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qje OCA], [http://pdbe.org/6qje PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qje RCSB], [http://www.ebi.ac.uk/pdbsum/6qje PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qje ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[[http://www.uniprot.org/uniprot/GALK1_HUMAN GALK1_HUMAN]] Defects in GALK1 are the cause of galactosemia II (GALCT2) [MIM:[http://omim.org/entry/230200 230200]]. Galactosemia II is an autosomal recessive deficiency characterized by congenital cataracts during infancy and presenile cataracts in the adult population. The cataracts are secondary to accumulation of galactitol in the lenses.<ref>PMID:10521295</ref> <ref>PMID:10790206</ref> <ref>PMID:11231902</ref> <ref>PMID:11139256</ref> <ref>PMID:12694189</ref> <ref>PMID:15024738</ref>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/GALK1_HUMAN GALK1_HUMAN]] Major enzyme for galactose metabolism.
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Galactokinase]]
 +
[[Category: Arrowsmith, C]]
 +
[[Category: Bezerra, G A]]
 +
[[Category: Bountra, C]]
 +
[[Category: Brandao-Neto, J]]
 +
[[Category: Brennan, P]]
 +
[[Category: Douangamath, A]]
 +
[[Category: Edwards, A]]
[[Category: Foster, W]]
[[Category: Foster, W]]
-
[[Category: Brandao-Neto, J]]
+
[[Category: Krojer, T]]
[[Category: Lai, K]]
[[Category: Lai, K]]
-
[[Category: Bezerra, G.A]]
+
[[Category: Mackinnon, S R]]
-
[[Category: Yue, W.W]]
+
[[Category: Yue, W W]]
-
[[Category: Arrowsmith, C]]
+
[[Category: Zhang, M]]
[[Category: Zhang, M]]
-
[[Category: Edwards, A]]
+
[[Category: Fragment]]
-
[[Category: Douangamath, A]]
+
[[Category: Fragment-bound]]
-
[[Category: Mackinnon, S.R]]
+
[[Category: Galactokinase 1]]
-
[[Category: Krojer, T]]
+
[[Category: Galk1]]
-
[[Category: Brennan, P]]
+
[[Category: Sugar kinase]]
-
[[Category: Bountra, C]]
+
[[Category: Transferase]]

Revision as of 15:37, 27 February 2019

Structure of human galactokinase 1 bound with 4-{[2-(Methylsulfonyl)-1H-imidazol-1-yl]methyl}-1,3-thiazole

6qje, resolution 2.40Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6qje"
Personal tools