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| | ==X-ray structure of NdhS from T. elongatus== | | ==X-ray structure of NdhS from T. elongatus== |
| - | <StructureSection load='6a7k' size='340' side='right' caption='[[6a7k]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='6a7k' size='340' side='right'caption='[[6a7k]], [[Resolution|resolution]] 1.90Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6a7k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Theeb Theeb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A7K FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6a7k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermosynechococcus_vestitus_BP-1 Thermosynechococcus vestitus BP-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A7K FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tlr0636 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=197221 THEEB])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a7k OCA], [http://pdbe.org/6a7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a7k RCSB], [http://www.ebi.ac.uk/pdbsum/6a7k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a7k ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a7k OCA], [https://pdbe.org/6a7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a7k RCSB], [https://www.ebi.ac.uk/pdbsum/6a7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a7k ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q8DL61_THEVB Q8DL61_THEVB] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Theeb]] | + | [[Category: Large Structures]] |
| - | [[Category: Kurisu, G]] | + | [[Category: Thermosynechococcus vestitus BP-1]] |
| - | [[Category: Misumi, Y]] | + | [[Category: Kurisu G]] |
| - | [[Category: Tanaka, H]] | + | [[Category: Misumi Y]] |
| - | [[Category: Umeno, K]] | + | [[Category: Tanaka H]] |
| - | [[Category: Electron transport]]
| + | [[Category: Umeno K]] |
| - | [[Category: Ferredoxin]]
| + | |
| - | [[Category: Nadh dehydrogenase-like complex]]
| + | |
| - | [[Category: Ndh-1]]
| + | |
| Structural highlights
Function
Q8DL61_THEVB
Publication Abstract from PubMed
Photosynthetic complex I enables cyclic electron flow around photosystem I, a regulatory mechanism for photosynthetic energy conversion. We report a 3.3-A resolution cryo-EM structure of photosynthetic complex I from the cyanobacterium Thermosynechococcus elongatus. The model reveals structural adaptations that facilitate binding and electron transfer from the photosynthetic electron carrier ferredoxin. By mimicking cyclic electron flow with isolated components in vitro, we demonstrate that ferredoxin directly mediates electron transfer between photosystem I and complex I, instead of using intermediates such as NADPH. A large rate constant for association of ferredoxin to complex I indicates efficient recognition, with the protein subunit NdhS being the key component in this process.
Structural adaptations of photosynthetic complex I enable ferredoxin-dependent electron transfer.,Schuller JM, Birrell JA, Tanaka H, Konuma T, Wulfhorst H, Cox N, Schuller SK, Thiemann J, Lubitz W, Setif P, Ikegami T, Engel BD, Kurisu G, Nowaczyk MM Science. 2018 Dec 20. pii: science.aau3613. doi: 10.1126/science.aau3613. PMID:30573545[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Schuller JM, Birrell JA, Tanaka H, Konuma T, Wulfhorst H, Cox N, Schuller SK, Thiemann J, Lubitz W, Setif P, Ikegami T, Engel BD, Kurisu G, Nowaczyk MM. Structural adaptations of photosynthetic complex I enable ferredoxin-dependent electron transfer. Science. 2018 Dec 20. pii: science.aau3613. doi: 10.1126/science.aau3613. PMID:30573545 doi:http://dx.doi.org/10.1126/science.aau3613
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