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3o4f

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==Crystal Structure of Spermidine Synthase from E. coli==
==Crystal Structure of Spermidine Synthase from E. coli==
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<StructureSection load='3o4f' size='340' side='right' caption='[[3o4f]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='3o4f' size='340' side='right'caption='[[3o4f]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3o4f]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3adn 3adn] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3hh9 3hh9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O4F FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3o4f]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3adn 3adn] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3hh9 3hh9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O4F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPEE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPEE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Spermidine_synthase Spermidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.16 2.5.1.16] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Spermidine_synthase Spermidine synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.16 2.5.1.16] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4f OCA], [http://pdbe.org/3o4f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o4f RCSB], [http://www.ebi.ac.uk/pdbsum/3o4f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o4f ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4f OCA], [https://pdbe.org/3o4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o4f RCSB], [https://www.ebi.ac.uk/pdbsum/3o4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o4f ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SPEE_ECOLI SPEE_ECOLI]] Involved in the biosynthesis of polyamines which play a significant role in the structural and functional organization in the chromoid of E.coli by compacting DNA and neutralizing negative charges. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. Cadaverine (1,5-diaminopentane) and spermidine can replace putrescine as the propylamine acceptor.<ref>PMID:23001854</ref> <ref>PMID:4572733</ref>
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[[https://www.uniprot.org/uniprot/SPEE_ECOLI SPEE_ECOLI]] Involved in the biosynthesis of polyamines which play a significant role in the structural and functional organization in the chromoid of E.coli by compacting DNA and neutralizing negative charges. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. Cadaverine (1,5-diaminopentane) and spermidine can replace putrescine as the propylamine acceptor.<ref>PMID:23001854</ref> <ref>PMID:4572733</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Spermidine Synthase|Spermidine Synthase]]
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*[[Spermidine synthase 3D structures|Spermidine synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Ecoli]]
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[[Category: Large Structures]]
[[Category: Spermidine synthase]]
[[Category: Spermidine synthase]]
[[Category: Chruszcz, M]]
[[Category: Chruszcz, M]]

Revision as of 09:56, 13 April 2022

Crystal Structure of Spermidine Synthase from E. coli

PDB ID 3o4f

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