Caspase
From Proteopedia
(Difference between revisions)
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* '''Metacaspase''' (MCASP) are arginine/lysine specific CASP. MCASP are found in plants and fungi. | * '''Metacaspase''' (MCASP) are arginine/lysine specific CASP. MCASP are found in plants and fungi. | ||
<ref>PMID:12920126</ref><ref>PMID:8035875</ref> | <ref>PMID:12920126</ref><ref>PMID:8035875</ref> | ||
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| + | ==3D structures of caspase== | ||
| + | [[Caspase 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
==3D structures of caspase== | ==3D structures of caspase== | ||
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**[[1sc1]], [[1sc4]] - hCASP (mutant) <br /> | **[[1sc1]], [[1sc4]] - hCASP (mutant) <br /> | ||
**[[1sc3]] - hCASP (mutant) + malonate<br /> | **[[1sc3]] - hCASP (mutant) + malonate<br /> | ||
| - | **[[3d6f]], [[3d6h]], [[3d6m]], [[1ibc]], [[5mtk]], [[5mmv]] - hCASP (mutant) + polypeptide inhibitor<br /> | + | **[[6bz9]] - hCASP + polypeptide inhibitor<br /> |
| + | **[[3d6f]], [[3d6h]], [[3d6m]], [[1ibc]], [[5mtk]], [[5mmv]], [[6f6r]] - hCASP (mutant) + polypeptide inhibitor<br /> | ||
**[[2hbq]], [[1bmq]], [[3ns7]] - hCASP + inhibitor<br /> | **[[2hbq]], [[1bmq]], [[3ns7]] - hCASP + inhibitor<br /> | ||
**[[2h4w]], [[2h4y]], [[2h51]], [[2h54]], [[2hbr]], [[2hby]], [[2hbz]], [[2h48]], [[2fqq]], [[1rwk]], [[1rwm]], [[1rwn]], [[1rwo]], [[1rwp]], [[1rwv]], [[1rww]], [[1rwx]] - hCASP (mutant) + inhibitor<br /> | **[[2h4w]], [[2h4y]], [[2h51]], [[2h54]], [[2hbr]], [[2hby]], [[2hbz]], [[2h48]], [[2fqq]], [[1rwk]], [[1rwm]], [[1rwn]], [[1rwo]], [[1rwp]], [[1rwv]], [[1rww]], [[1rwx]] - hCASP (mutant) + inhibitor<br /> | ||
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**[[3p45]], [[3k7e]], [[2wdp]] – hCASP<br /> | **[[3p45]], [[3k7e]], [[2wdp]] – hCASP<br /> | ||
| - | **[[3nkf]], [[3nr2]], [[3s8e]], [[3v6l]], [[3v6m]], [[4iyr]] – hCASP (mutant) <br /> | + | **[[3nkf]], [[3nr2]], [[3s8e]], [[3v6l]], [[3v6m]], [[4iyr]], [[6dev]], [[6deu]] – hCASP (mutant) <br /> |
**[[3od5]], [[3p4u]], [[3qnw]], [[3s70]] – hCASP + polypeptide inhibitor<br /> | **[[3od5]], [[3p4u]], [[3qnw]], [[3s70]] – hCASP + polypeptide inhibitor<br /> | ||
**[[4ejf]] – hCASP subunit P11 + P18 + polypeptide<br /> | **[[4ejf]] – hCASP subunit P11 + P18 + polypeptide<br /> | ||
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**[[1i4o]] - hCASP P20 subunit + XIAP<br /> | **[[1i4o]] - hCASP P20 subunit + XIAP<br /> | ||
**[[4jb8]], [[4lsz]] - hCASP large+small subunits + DARPIN<br /> | **[[4jb8]], [[4lsz]] - hCASP large+small subunits + DARPIN<br /> | ||
| - | **[[5ic6]], [[5ic4]], [[4zvo]], [[4zvp]], [[4zvq]], [[4zvr]], [[4zvs]], [[4zvt]], [[4zvu]] - hCASP large+small subunits + peptide inhibitor<br /> | + | **[[5ic6]], [[5ic4]], [[4zvo]], [[4zvp]], [[4zvq]], [[4zvr]], [[4zvs]], [[4zvt]], [[4zvu]], [[6cl2]], [[6cl1]], [[6cl0]], [[6ckz]] - hCASP large+small subunits + peptide inhibitor<br /> |
*CASP-8 | *CASP-8 | ||
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**[[5l08]] – hCASP – Cryo-EM<br /> | **[[5l08]] – hCASP – Cryo-EM<br /> | ||
**[[4zbw]] - hCASP death effector domain<br /> | **[[4zbw]] - hCASP death effector domain<br /> | ||
| - | **[[5h33]] - hCASP death effector domain (mutant)<br /> | + | **[[5h33]], [[5h31]] - hCASP death effector domain (mutant)<br /> |
**[[3kjn]], [[3kjq]] – hCASP subunit P18 + inhibitor<br /> | **[[3kjn]], [[3kjq]] – hCASP subunit P18 + inhibitor<br /> | ||
**[[1f9e]], [[1qtn]], [[1qdu]] - hCASP subunit α,β + polypeptide inhibitor<br /> | **[[1f9e]], [[1qtn]], [[1qdu]] - hCASP subunit α,β + polypeptide inhibitor<br /> | ||
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**[[1jxq]] - hCASP + polypeptide inhibitor<br /> | **[[1jxq]] - hCASP + polypeptide inhibitor<br /> | ||
**[[3v3k]] – hCASP + effector protein<br /> | **[[3v3k]] – hCASP + effector protein<br /> | ||
| - | **[[5wve]], [[5juy]] – hCASP CARD domain + APAF-1<br /> | + | **[[5wve]], [[5juy]], [[5wvc]] – hCASP CARD domain + APAF-1<br /> |
**[[1nw9]] – hCASP catalytic domain + XIAP-BIR3<br /> | **[[1nw9]] – hCASP catalytic domain + XIAP-BIR3<br /> | ||
**[[3ygs]], [[4rhw]] – hpro-CASP + APAF-1 CARD | **[[3ygs]], [[4rhw]] – hpro-CASP + APAF-1 CARD | ||
Revision as of 09:57, 28 April 2019
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3D structures of caspase
Updated on 28-April-2019
4jqy, 4jqz - hpro-CASP (mutant)
References
- ↑ Schweizer A, Briand C, Grutter MG. Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway. J Biol Chem. 2003 Oct 24;278(43):42441-7. Epub 2003 Aug 14. PMID:12920126 doi:http://dx.doi.org/10.1074/jbc.M304895200
- ↑ Wilson KP, Black JA, Thomson JA, Kim EE, Griffith JP, Navia MA, Murcko MA, Chambers SP, Aldape RA, Raybuck SA, et al.. Structure and mechanism of interleukin-1 beta converting enzyme. Nature. 1994 Jul 28;370(6487):270-5. PMID:8035875 doi:http://dx.doi.org/10.1038/370270a0
