Cell division protein

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 2: Line 2:
== Function ==
== Function ==
-
'''Cell Division Protein FtsZ''' (Ftsz) is the prokaryotic homolog of tubulin. Ftsz assembles into a ring at the site of the septum in bacterial cell division. Ftsz stands for Filamenting Temperature-Sensitive mutant Z. Ftsz can bind GTP and hydrolyze it to GDP<ref>PMID:15558053</ref>. '''ZapA, ZapB, ZapC, ZapD''' (Z-Associated Protein) are regulators which modulate the dynamics of the FtsZ ring at midcell division site<ref>PMID:21216995</ref>.
+
'''Cell Division Protein FtsZ''' (Ftsz) is the prokaryotic homolog of tubulin. Ftsz assembles into a ring at the site of the septum in bacterial cell division. Ftsz stands for Filamenting Temperature-Sensitive mutant Z. Ftsz can bind GTP and hydrolyze it to GDP<ref>PMID:15558053</ref>. '''Ftsq''' us another septal protein. It is biopic membrane protein which is recruited in cell division site<ref>PMID:9882666</ref>. ''ZapA, ZapB, ZapC, ZapD''' (Z-Associated Protein) are regulators which modulate the dynamics of the FtsZ ring at midcell division site<ref>PMID:21216995</ref>.
== Structural highlights ==
== Structural highlights ==
<scene name='47/473540/Cv/4'>The GTP binding site</scene> (PDB code [[1w5b]]). Water molecules are shown as red spheres.
<scene name='47/473540/Cv/4'>The GTP binding site</scene> (PDB code [[1w5b]]). Water molecules are shown as red spheres.
 +
 +
== 3D Structures of cell division protein ==
 +
[[Cell division protein 3D structures]]
 +
</StructureSection>
</StructureSection>
== 3D Structures of cell division protein ==
== 3D Structures of cell division protein ==
Line 31: Line 35:
**[[2vaw]] - PaFtsz + GDP<BR />
**[[2vaw]] - PaFtsz + GDP<BR />
**[[1rlu]], [[2q1y]] – MtFtsz + γ-S-GTP – ''Mycobacterium tuberculosis''<BR />
**[[1rlu]], [[2q1y]] – MtFtsz + γ-S-GTP – ''Mycobacterium tuberculosis''<BR />
-
**[[4b45]] - HvFtsz + γ-S-GTP – ''Haloferax volcanii''<br />
 
-
**[[4b46]] - VoFtsz + GDP<br />
 
**[[1rq7]], [[4kwe]], [[5v68]] - MtFtsz + GDP<BR />
**[[1rq7]], [[4kwe]], [[5v68]] - MtFtsz + GDP<BR />
 +
**[[5zue]] - MtFtsz (mutant) + GTP<br />
**[[1rq2]], [[2q1x]] – MtFtsz + citrate<BR />
**[[1rq2]], [[2q1x]] – MtFtsz + citrate<BR />
 +
**[[4b45]] - HvFtsz + γ-S-GTP – ''Haloferax volcanii''<br />
 +
**[[4b46]] - VoFtsz + GDP<br />
**[[1w58]] – MjFtsz + GMP-CPP <BR />
**[[1w58]] – MjFtsz + GMP-CPP <BR />
**[[1w5b]] - MjFtsz + GTP<BR />
**[[1w5b]] - MjFtsz + GTP<BR />
Line 53: Line 58:
**[[4oom]], [[4ool]] – PaFtsi + inhibior <br />
**[[4oom]], [[4ool]] – PaFtsi + inhibior <br />
 +
 +
*Ftsq
 +
 +
**[[6h9o]], [[6h9n]], [[5z2w]] – EcFtsq residues 58-276 + EcFtsb residues 64-87 <br />
*Ftsx
*Ftsx
**[[4n8o]], [[4n8n]] – MtFtsx extracellular domain <br />
**[[4n8o]], [[4n8n]] – MtFtsx extracellular domain <br />
 +
**[[6hfx]] – SpFtsx extracellular loop – ''Streptococcus pneumoniae'' <br />
 +
**[[6mk7]] – SpFtsx extracellular loop - NMR <br />
 +
**[[6hee]], [[6he6]] – SpFtsx extracellular loop + peptidoglycan <br />
*ZapA
*ZapA

Revision as of 09:03, 5 May 2019

Ftsz complex with GTP (PDB code 1w5b)

Drag the structure with the mouse to rotate

3D Structures of cell division protein

Updated on 05-May-2019

References

  1. ↑ Oliva MA, Cordell SC, Lowe J. Structural insights into FtsZ protofilament formation. Nat Struct Mol Biol. 2004 Dec;11(12):1243-50. Epub 2004 Nov 21. PMID:15558053 doi:10.1038/nsmb855
  2. ↑ Chen JC, Weiss DS, Ghigo JM, Beckwith J. Septal localization of FtsQ, an essential cell division protein in Escherichia coli. J Bacteriol. 1999 Jan;181(2):521-30. PMID:9882666
  3. ↑ Durand-Heredia JM, Yu HH, De Carlo S, Lesser CF, Janakiraman A. Identification and characterization of ZapC, a stabilizer of the FtsZ ring in Escherichia coli. J Bacteriol. 2011 Mar;193(6):1405-13. doi: 10.1128/JB.01258-10. Epub 2011 Jan 7. PMID:21216995 doi:http://dx.doi.org/10.1128/JB.01258-10
Retrieved from "http://52.214.119.220/wiki/index.php/Cell_division_protein"
Personal tools