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Cellobiohydrolase

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The <scene name='48/488493/Cv/6'>active site</scene> of CBH contains <scene name='48/488493/Cv/7'>Glu-Asp-Glu</scene> (Gln-Asp-Glu in [[3cel]], cyan) and is situated at the <scene name='48/488493/Cv/9'>bottom of a tunnel</scene>.<ref>PMID:8951380</ref> Water molecules shown as red spheres.
The <scene name='48/488493/Cv/6'>active site</scene> of CBH contains <scene name='48/488493/Cv/7'>Glu-Asp-Glu</scene> (Gln-Asp-Glu in [[3cel]], cyan) and is situated at the <scene name='48/488493/Cv/9'>bottom of a tunnel</scene>.<ref>PMID:8951380</ref> Water molecules shown as red spheres.
 +
 +
==3D structures of cellobiohydrolase==
 +
[[Cellobiohydrolase 3D structures]]
 +
</StructureSection>
</StructureSection>
==3D structures of cellobiohydrolase==
==3D structures of cellobiohydrolase==
Line 18: Line 22:
**[[1cel]], [[4p1h]], [[4p1j]], [[5tc9]] – HjCBHI Cel7A catalytic domain – ''Hypocrea jecorina''<BR />
**[[1cel]], [[4p1h]], [[4p1j]], [[5tc9]] – HjCBHI Cel7A catalytic domain – ''Hypocrea jecorina''<BR />
-
**[[2cel]], [[4cel]], [[1egn]], [[1q2b]] - HjCBHI catalytic domain (mutant) <BR />
+
**[[2cel]], [[4cel]], [[1egn]], [[1q2b]], [[5oa5]] - HjCBHI catalytic domain (mutant) <BR />
**[[1cbh]], [[2cbh]], [[5x34]], [[5x35]], [[5x36]], [[5x37]], [[5x38]] – HjCBHI C terminal – NMR<BR />
**[[1cbh]], [[2cbh]], [[5x34]], [[5x35]], [[5x36]], [[5x37]], [[5x38]] – HjCBHI C terminal – NMR<BR />
-
**[[5x3c]] – HjCBHI C terminal (mutant) – NMR<br />
+
**[[5x3c]], [[5x39]] – HjCBHI C terminal (mutant) – NMR<br />
**[[1azh]], [[1az6]], [[1azj]], [[1azk]] - HjCBHI cellulose-binding domain (mutant) - NMR<BR />
**[[1azh]], [[1az6]], [[1azj]], [[1azk]] - HjCBHI cellulose-binding domain (mutant) - NMR<BR />
**[[1gpi]] - PcCBHI Cel7D catalytic domain – ''Phanerochaete chrysosporium''<BR />
**[[1gpi]] - PcCBHI Cel7D catalytic domain – ''Phanerochaete chrysosporium''<BR />
Line 28: Line 32:
**[[4zzv]], [[5amp]] - GcCBHI Cel7A catalytic domain – ''Galactomyces candidum''<br />
**[[4zzv]], [[5amp]] - GcCBHI Cel7A catalytic domain – ''Galactomyces candidum''<br />
**[[2mwk]], [[2mwj]] - TrCBHI Cel7A carbohydrate-binding module 1 domain – ''Trichoderma reesei''<br />
**[[2mwk]], [[2mwj]] - TrCBHI Cel7A carbohydrate-binding module 1 domain – ''Trichoderma reesei''<br />
 +
**[[4v1z]] – AfCBH Cel7A – ''Aspergillus fumigatus''<br />
*''Cellobiohydrolase I binary complex''
*''Cellobiohydrolase I binary complex''
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**[[7cel]] - HjCBHI catalytic domain (mutant) + glucose<br />
**[[7cel]] - HjCBHI catalytic domain (mutant) + glucose<br />
**[[2v3i]], [[2v3r]] - HjCBHI Cel7A catalytic domain + phenanthrenolol<br />
**[[2v3i]], [[2v3r]] - HjCBHI Cel7A catalytic domain + phenanthrenolol<br />
-
**[[1dy4]] - TrCBHI Cel7A catalytic domain + propranolol <BR />
+
**[[1dy4]], [[6grn]] - TrCBHI Cel7A catalytic domain + propranolol derivative<BR />
 +
**[[4v0z]] - TrCBH Cel7A catalytic domain + cellobiose<br />
 +
**[[4vwt]] - TrCBH Cel7A (mutant) catsalytic domain + cellobiose<br />
**[[4c4c]] - TrCBHI Cel7A catalytic domain (mutant) + cellononaose <br />
**[[4c4c]] - TrCBHI Cel7A catalytic domain (mutant) + cellononaose <br />
**[[4c4d]], [[4d5i]], [[4d5j]] - TrCBHI Cel7A catalytic domain (mutant) + cellotrioside <br />
**[[4c4d]], [[4d5i]], [[4d5j]] - TrCBHI Cel7A catalytic domain (mutant) + cellotrioside <br />
-
**[[1h46]] - PcCBHI Cel7D catalytic domain + propranolol<br />
 
-
**[[1z3t]] - PcCBHI Cel7D catalytic domain + cellobiose<br />
 
-
**[[1z3v]] - PcCBHI Cel7D catalytic domain + lactose<br />
 
-
**[[1z3w]] - PcCBHI Cel7D catalytic domain + cellobioimidazole<BR />
 
**[[3pfx]] - TeCBHI Cel7A catalytic domain + cellobiose<br />
**[[3pfx]] - TeCBHI Cel7A catalytic domain + cellobiose<br />
**[[3pfz]] - TeCBHI Cel7A catalytic domain + cellotetraose + cellobiose<br />
**[[3pfz]] - TeCBHI Cel7A catalytic domain + cellotetraose + cellobiose<br />
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**[[5o5d]] - HaCBHI Cel7A catalytic domain – ''Hypocrea atroviridis''<br />
**[[5o5d]] - HaCBHI Cel7A catalytic domain – ''Hypocrea atroviridis''<br />
**[[5o59]] - HaCBHI Cel7A catalytic domain + glucose <br />
**[[5o59]] - HaCBHI Cel7A catalytic domain + glucose <br />
 +
**[[4v20]] - AfCBH Cel7A catalytic domain + disaccharide<br />
 +
**[[1h46]] - PcCBHI Cel7D catalytic domain + propranolol<br />
 +
**[[1z3t]] - PcCBHI Cel7D catalytic domain + cellobiose<br />
 +
**[[1z3v]] - PcCBHI Cel7D catalytic domain + lactose<br />
 +
**[[1z3w]] - PcCBHI Cel7D catalytic domain + cellobioimidazole<BR />
*Cellobiohydrolase II or Cellobiohydrolase Cel6A or exoglucanase 2
*Cellobiohydrolase II or Cellobiohydrolase Cel6A or exoglucanase 2
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**[[1qk0]] - TrCBHII Cel6A catalytic domain + polysaccharide<BR />
**[[1qk0]] - TrCBHII Cel6A catalytic domain + polysaccharide<BR />
**[[1qk2]] - TrCBHII Cel6A catalytic domain + cellotetraose<br />
**[[1qk2]] - TrCBHII Cel6A catalytic domain + cellotetraose<br />
 +
**[[4a05]] - CBHII Cel6A catalytic domain + cellotetraose – ''Chaetonium thermophilum''<br />
*Other cellobiohydrolases
*Other cellobiohydrolases
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**[[3a64]], [[3vog]] - CcCBH Cel6C catalytic domain - ''Coprinopsis cinerea''<BR />
**[[3a64]], [[3vog]] - CcCBH Cel6C catalytic domain - ''Coprinopsis cinerea''<BR />
**[[3vof]], [[3voj]] - CcCBHI Cel6C catalytic domain (mutant)<br />
**[[3vof]], [[3voj]] - CcCBHI Cel6C catalytic domain (mutant)<br />
-
**[[4v1z]] – AfCBH Cel7A – ''Aspergillus fumigatus''<br />
 
**[[2mte]] – CBH CelS residues 673-741 – ''Ruminiclostridium thermocellum'' - NMR<br />
**[[2mte]] – CBH CelS residues 673-741 – ''Ruminiclostridium thermocellum'' - NMR<br />
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**[[1l2a]] - CtCBH CelS + glucose<br />
**[[1l2a]] - CtCBH CelS + glucose<br />
**[[2ebs]] – GgCBH (mutant) + heptasaccharide<BR />
**[[2ebs]] – GgCBH (mutant) + heptasaccharide<BR />
 +
**[[4avn]] - CBH Cel6B + cellobiose – Thermobifidia fusca<br />
**[[3a9b]], [[3voh]] - CcCBHI Cel6C catalytic domain + cellobiose<br />
**[[3a9b]], [[3voh]] - CcCBHI Cel6C catalytic domain + cellobiose<br />
**[[3abx]], [[3voi]] - CcCBHI Cel6C catalytic domain + cellotriose<br />
**[[3abx]], [[3voi]] - CcCBHI Cel6C catalytic domain + cellotriose<br />
**[[4v20]] - AfCBH Cel7A + disaccharide<br />
**[[4v20]] - AfCBH Cel7A + disaccharide<br />
-
**[[4v0z]] - TrCBH Cel7A + cellobiose<br />
 
-
**[[4vwt]] - TrCBH Cel7A (mutant) + cellobiose<br />
 
}}
}}

Revision as of 09:44, 5 May 2019

Glycosylated cellobiohydrolase I catalytic domain complex with cellobiose and Cd+2 ions (PDB code 3cel)

Drag the structure with the mouse to rotate

3D structures of cellobiohydrolase

Updated on 05-May-2019

References

  1. ↑ Divne C, Stahlberg J, Teeri TT, Jones TA. High-resolution crystal structures reveal how a cellulose chain is bound in the 50 A long tunnel of cellobiohydrolase I from Trichoderma reesei. J Mol Biol. 1998 Jan 16;275(2):309-25. PMID:9466911 doi:http://dx.doi.org/10.1006/jmbi.1997.1437
  2. ↑ Stahlberg J, Divne C, Koivula A, Piens K, Claeyssens M, Teeri TT, Jones TA. Activity studies and crystal structures of catalytically deficient mutants of cellobiohydrolase I from Trichoderma reesei. J Mol Biol. 1996 Nov 29;264(2):337-49. PMID:8951380 doi:http://dx.doi.org/10.1006/jmbi.1996.0644

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Michal Harel, Alexander Berchansky, Karsten Theis

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