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6h05

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'''Unreleased structure'''
 
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The entry 6h05 is ON HOLD
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==Cryo-electron microscopic structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate (2-oxoglutarate) dehydrogenase complex [residues 218-453]==
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<StructureSection load='6h05' size='340' side='right'caption='[[6h05]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6h05]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H05 FirstGlance]. <br>
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Description:
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_succinyltransferase Dihydrolipoyllysine-residue succinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.61 2.3.1.61] </span></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h05 OCA], [http://pdbe.org/6h05 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h05 RCSB], [http://www.ebi.ac.uk/pdbsum/6h05 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h05 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ODO2_HUMAN ODO2_HUMAN]] Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711).[UniProtKB:Q9N0F1]<ref>PMID:29211711</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Dihydrolipoyllysine-residue succinyltransferase]]
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[[Category: Large Structures]]
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[[Category: Adam-Vizi, V]]
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[[Category: Ambrus, A]]
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[[Category: Hubert, A]]
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[[Category: Jordan, F]]
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[[Category: Nagy, B]]
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[[Category: Nemeria, N S]]
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[[Category: Novacek, J]]
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[[Category: Polak, M]]
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[[Category: Zambo, Z]]
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[[Category: 2-oxoglutarate dehydrogenase complex]]
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[[Category: Alpha-ketoglutarate dehydrogenase complex]]
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[[Category: Dihydrolipoamide succinyltransferase]]
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[[Category: E2 component]]
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[[Category: Transferase]]

Revision as of 16:05, 22 January 2020

Cryo-electron microscopic structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate (2-oxoglutarate) dehydrogenase complex [residues 218-453]

PDB ID 6h05

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OCA

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