2qog

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(New page: 200px {{Structure |PDB= 2qog |SIZE=350|CAPTION= <scene name='initialview01'>2qog</scene>, resolution 2.28&Aring; |SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+F...)
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[[Image:2qog.jpg|left|200px]]
[[Image:2qog.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2qog |SIZE=350|CAPTION= <scene name='initialview01'>2qog</scene>, resolution 2.28&Aring;
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The line below this paragraph, containing "STRUCTURE_2qog", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Residue+B+134'>AC1</scene> and <scene name='pdbsite=AC2:Ca+Binding+Site+For+Residue+C+134'>AC2</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00125 PLA2c]</span>
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{{STRUCTURE_2qog| PDB=2qog | SCENE= }}
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|RELATEDENTRY=[[2ok9|2OK9]], [[2oqd|2OQD]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qog OCA], [http://www.ebi.ac.uk/pdbsum/2qog PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qog RCSB]</span>
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}}
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'''Crotoxin B, the basic PLA2 from Crotalus durissus terrificus.'''
'''Crotoxin B, the basic PLA2 from Crotalus durissus terrificus.'''
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Insights into the role of oligomeric state on the biological activities of crotoxin: Crystal structure of a tetrameric phospholipase A(2) formed by two isoforms of crotoxin B from Crotalus durissus terrificus venom., Marchi-Salvador DP, Correa LC, Magro AJ, Oliveira CZ, Soares AM, Fontes MR, Proteins. 2008 Feb 14;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18275084 18275084]
Insights into the role of oligomeric state on the biological activities of crotoxin: Crystal structure of a tetrameric phospholipase A(2) formed by two isoforms of crotoxin B from Crotalus durissus terrificus venom., Marchi-Salvador DP, Correa LC, Magro AJ, Oliveira CZ, Soares AM, Fontes MR, Proteins. 2008 Feb 14;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18275084 18275084]
[[Category: Crotalus durissus terrificus]]
[[Category: Crotalus durissus terrificus]]
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[[Category: Phospholipase A(2)]]
 
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Correa, L C.]]
[[Category: Correa, L C.]]
[[Category: Fontes, M R.M.]]
[[Category: Fontes, M R.M.]]
[[Category: Marchi-Salvador, D P.]]
[[Category: Marchi-Salvador, D P.]]
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[[Category: calcium]]
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[[Category: Calcium]]
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[[Category: crotoxin b cd-cdt basic-pla2]]
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[[Category: Crotoxin b cd-cdt basic-pla2]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: lipid degradation]]
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[[Category: Lipid degradation]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: neurotoxin]]
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[[Category: Neurotoxin]]
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[[Category: presynaptic neurotoxin]]
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[[Category: Presynaptic neurotoxin]]
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[[Category: secreted]]
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[[Category: Secreted]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:18:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 2 11:58:16 2008''
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Revision as of 12:18, 4 May 2008

Image:2qog.jpg

Template:STRUCTURE 2qog

Crotoxin B, the basic PLA2 from Crotalus durissus terrificus.


Overview

Crotoxin B (CB or Cdt PLA(2)) is a basic Asp49-PLA(2) found in the venom of Crotalus durissus terrificus and it is one of the subunits that constitute the crotoxin (Cro). This heterodimeric toxin, main component of the C. d. terrificus venom, is completed by an acidic, nontoxic, and nonenzymatic component (crotoxin A, CA or crotapotin), and it is related to important envenomation effects such as neurological disorders, myotoxicity, and renal failure. Although Cro has been crystallized since 1938, no crystal structure of this toxin or its subunits is currently available. In this work, the authors present the crystal structure of a novel tetrameric complex formed by two dimers of crotoxin B isoforms (CB1 and CB2). The results suggest that these assemblies are stable in solution and show that Ser1 and Glu92 of CB1 and CB2, respectively, play an important role in the oligomerization. The tetrameric and dimeric conformations resulting from the association of the isoforms may increase the neurotoxicity of the toxin CB by the creation of new binding sites, which could improve the affinity of the molecular complexes to the presynaptic membrane. Proteins 2008. (c) 2008 Wiley-Liss, Inc.

About this Structure

2QOG is a Protein complex structure of sequences from Crotalus durissus terrificus. Full crystallographic information is available from OCA.

Reference

Insights into the role of oligomeric state on the biological activities of crotoxin: Crystal structure of a tetrameric phospholipase A(2) formed by two isoforms of crotoxin B from Crotalus durissus terrificus venom., Marchi-Salvador DP, Correa LC, Magro AJ, Oliveira CZ, Soares AM, Fontes MR, Proteins. 2008 Feb 14;. PMID:18275084 Page seeded by OCA on Sun May 4 15:18:38 2008

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