3beg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px {{Structure |PDB= 3beg |SIZE=350|CAPTION= <scene name='initialview01'>3beg</scene>, resolution 2.900&Aring; |SITE= <scene name='pdbsite=AC1:Sep+Binding+Site...)
Line 1: Line 1:
[[Image:3beg.jpg|left|200px]]
[[Image:3beg.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 3beg |SIZE=350|CAPTION= <scene name='initialview01'>3beg</scene>, resolution 2.900&Aring;
+
The line below this paragraph, containing "STRUCTURE_3beg", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Sep+Binding+Site+For+Residue+A+1'>AC1</scene>, <scene name='pdbsite=AC2:ALA+Binding+Site+For+Residue+A+2'>AC2</scene> and <scene name='pdbsite=AC3:Anp+Binding+Site+For+Residue+A+656'>AC3</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= SRPK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), SFRS1, ASF, SF2, SF2P33 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00220 S_TKc], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00180 S_TKc], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00076 RRM_1]</span>
+
{{STRUCTURE_3beg| PDB=3beg | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3beg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3beg OCA], [http://www.ebi.ac.uk/pdbsum/3beg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3beg RCSB]</span>
+
-
}}
+
'''Crystal structure of SR protein kinase 1 complexed to its substrate ASF/SF2'''
'''Crystal structure of SR protein kinase 1 complexed to its substrate ASF/SF2'''
Line 26: Line 23:
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Protein complex]]
[[Category: Protein complex]]
 +
[[Category: Adams, J A.]]
 +
[[Category: Chakrabarti, S.]]
 +
[[Category: Dorrestein, P C.]]
 +
[[Category: Fu, X D.]]
 +
[[Category: Ghosh, G.]]
 +
[[Category: Giang, K.]]
 +
[[Category: Hagopian, J.]]
 +
[[Category: Huynh, N.]]
 +
[[Category: Ma, C T.]]
[[Category: Ngo, J C.]]
[[Category: Ngo, J C.]]
-
[[Category: acetylation]]
+
[[Category: Acetylation]]
-
[[Category: alternative splicing]]
+
[[Category: Alternative splicing]]
-
[[Category: atp-binding]]
+
[[Category: Atp-binding]]
-
[[Category: chromosome partition]]
+
[[Category: Chromosome partition]]
-
[[Category: cytoplasm]]
+
[[Category: Cytoplasm]]
-
[[Category: differentiation]]
+
[[Category: Differentiation]]
-
[[Category: kinase]]
+
[[Category: Kinase]]
-
[[Category: methylation]]
+
[[Category: Methylation]]
-
[[Category: mrna processing]]
+
[[Category: Mrna processing]]
-
[[Category: nucleotide-binding]]
+
[[Category: Nucleotide-binding]]
-
[[Category: nucleus]]
+
[[Category: Nucleus]]
-
[[Category: phosphoprotein]]
+
[[Category: Phosphoprotein]]
-
[[Category: polymorphism]]
+
[[Category: Polymorphism]]
-
[[Category: pre-mrna splicing]]
+
[[Category: Pre-mrna splicing]]
-
[[Category: rna-binding]]
+
[[Category: Rna-binding]]
-
[[Category: serine/threonine-protein kinase]]
+
[[Category: Serine/threonine-protein kinase]]
-
[[Category: spliceosome]]
+
[[Category: Spliceosome]]
-
[[Category: sr protein]]
+
[[Category: Sr protein]]
-
[[Category: sr protein kinase]]
+
[[Category: Sr protein kinase]]
-
[[Category: transferase]]
+
[[Category: Transferase]]
-
[[Category: transferase/splicing complex]]
+
[[Category: Transferase/splicing complex]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 9 14:45:47 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 2 11:59:16 2008''
+

Revision as of 11:45, 9 April 2008

Image:3beg.jpg

Template:STRUCTURE 3beg

Crystal structure of SR protein kinase 1 complexed to its substrate ASF/SF2


Overview

The 2.9 A crystal structure of the core SRPK1:ASF/SF2 complex reveals that the N-terminal half of the basic RS domain of ASF/SF2, which is destined to be phosphorylated, is bound to an acidic docking groove of SRPK1 distal to the active site. Phosphorylation of ASF/SF2 at a single site in the C-terminal end of the RS domain generates a primed phosphoserine that binds to a basic site in the kinase. Biochemical experiments support a directional sliding of the RS peptide through the docking groove to the active site during phosphorylation, which ends with the unfolding of a beta strand of the RRM domain and binding of the unfolded region to the docking groove. We further suggest that the priming of the first serine facilitates directional substrate translocation and efficient phosphorylation.

About this Structure

3BEG is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1., Ngo JC, Giang K, Chakrabarti S, Ma CT, Huynh N, Hagopian JC, Dorrestein PC, Fu XD, Adams JA, Ghosh G, Mol Cell. 2008 Mar 14;29(5):563-76. PMID:18342604 Page seeded by OCA on Wed Apr 9 14:45:47 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3beg"
Personal tools