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Choline kinase

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The choline binds to CK in a <scene name='59/593958/Cv/5'>deep hydrophobic groove</scene> (PDB code [[2ckq]]; {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}) and the <scene name='59/593958/Cv/6'>ADP binds in a cleft</scene> (PDB code [[2ckp]]). <ref>PMID:17007874</ref>
The choline binds to CK in a <scene name='59/593958/Cv/5'>deep hydrophobic groove</scene> (PDB code [[2ckq]]; {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}) and the <scene name='59/593958/Cv/6'>ADP binds in a cleft</scene> (PDB code [[2ckp]]). <ref>PMID:17007874</ref>
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==3D structures of choline kinase==
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[[Choline kinase 3D structures]]
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</StructureSection>
</StructureSection>
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**[[2ckp]] – hCK α2 + ADP<br />
**[[2ckp]] – hCK α2 + ADP<br />
**[[2ckq]] – hCK α2 + phosphocholine<br />
**[[2ckq]] – hCK α2 + phosphocholine<br />
-
**[[3zm9]], [[4da5]], [[4br3]], [[5afv]], [[5eqe]], [[5eqp]], [[5eqy]], [[5ftg]], [[5fut]] – hCK α + inhibitor<br />
+
**[[3zm9]], [[4da5]], [[4br3]], [[5afv]], [[5eqe]], [[5eqp]], [[5eqy]], [[5ftg]], [[5fut]], [[5w6o]] – hCK α + inhibitor<br />
**[[3f2r]] – hCK α + hemicholinium-3<br />
**[[3f2r]] – hCK α + hemicholinium-3<br />
**[[3g15]] – hCK α + hemicholinium-3 + ADP<br />
**[[3g15]] – hCK α + hemicholinium-3 + ADP<br />

Revision as of 10:28, 12 May 2019

Structure of human choline kinase α2 complex with phosphocholine (PDB code 2ckq).

Drag the structure with the mouse to rotate

3D structures of choline kinase

Updated on 12-May-2019


References

  1. ↑ Malito E, Sekulic N, Too WC, Konrad M, Lavie A. Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine. J Mol Biol. 2006 Nov 24;364(2):136-51. Epub 2006 Sep 3. PMID:17007874 doi:10.1016/j.jmb.2006.08.084

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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