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Clp Protease

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CLP is a heterodimer containing an ATP-binding regulatory subunit A '''ClpA''' or Hsp100 in [[Heat Shock Proteins]] and catalytic subunit P '''ClpP'''. The proteolytic complex is composed of <scene name='50/508398/Cv/2'>2 heptameric rings of ClpP</scene> flanked by hexameric rings of ClpA. For full proteolytic activity ClpP must associate with one of two related ATPase subunits: ClpA and [[ClpX]].
CLP is a heterodimer containing an ATP-binding regulatory subunit A '''ClpA''' or Hsp100 in [[Heat Shock Proteins]] and catalytic subunit P '''ClpP'''. The proteolytic complex is composed of <scene name='50/508398/Cv/2'>2 heptameric rings of ClpP</scene> flanked by hexameric rings of ClpA. For full proteolytic activity ClpP must associate with one of two related ATPase subunits: ClpA and [[ClpX]].
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</StructureSection>
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==3D structures of Clp protease==
==3D structures of Clp protease==
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[[Clp protease 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*CLP P subunit
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**[[1tyf]], [[1yg6]] – EcCLP – ''Escherichia coli''<br />
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**[[1yg8]], [[3hln]] - EcCLP (mutant)<br />
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**[[2ds6]] - EcCLP Zinc-binding domain<br />
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**[[1y7o]] – CLP – ''Streptococcus pneumoniae''<br />
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**[[1tg6]] - CLP – human<br />
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**[[2f6i]], [[4gm2]], [[4hnk]] - CLP – ''Plasmodium falciparum''<br />
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**[[2cby]], [[2ce3]], [[2c8t]], [[4u0h]], [[5e0s]], [[5dzk]] - MtCLP – ''Mycobacterium tuberculosis''<br />
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**[[3fes]] - CLP – ''Clostridium difficile''<br />
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**[[3ktg]], [[3kth]], [[3tt6]] – BsCLP – ''Bacillus subtilis''<br />
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**[[3p2l]], [[5g1s]], [[5g1r]], [[5g1q]] - CLP – ''Francisella tulerensis''<br />
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**[[3q7h]] - CLP – ''Coxiella burnetii''<br />
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**[[3qwd]], [[3st9]], [[3sta]], [[3v5e]], [[4emm]], [[4mxi]] - SaCLP – ''Staphylococcus aureus''<br />
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**[[3v5i]], [[4emp]], [[5c90]] - SaCLP (mutant)<br />
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**[[2zl0]] - HpCLP – ''Helicobacter pylori''<br />
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**[[2zl3]] - HpCLP (mutant)<br />
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**[[4jcq]], [[4jct]], [[4ryf]] – LmCLP – ''Listeria monocytogenes''<br />
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**[[4jcr]] - LmCLP (mutant)<br />
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*''CLP P subunit complex''
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**[[2fzs]], [[3mt6]] - EcCLP + peptide<br />
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**[[2zl2]] - HpCLP + peptide<br />
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**[[2zl4]] - HpCLP (mutant) + peptide<br />
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**[[3kti]], [[3ktj]], [[3ktk]] - BsCLP + peptide<br />
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**[[3tt7]] - BsCLP + DFP<br />
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**[[4u0g]] – MtCLP + ADEP + agonist<br />
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**[[5dl1]] – SaCLP + inhibitor<br />
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**[[5dkp]] – CLP + ADEP – ''Neisseria meningitidis''<br />
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*CLP A subunit and CLP N see [[Heat Shock Proteins]] Hsp100
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 06:42, 14 May 2019

E. coli Clp protease catalytic subunit (PDB entry 1tyf)

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References

  1. ↑ Maurizi MR, Clark WP, Katayama Y, Rudikoff S, Pumphrey J, Bowers B, Gottesman S. Sequence and structure of Clp P, the proteolytic component of the ATP-dependent Clp protease of Escherichia coli. J Biol Chem. 1990 Jul 25;265(21):12536-45. PMID:2197275

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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