6nuf

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'''Unreleased structure'''
 
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The entry 6nuf is ON HOLD until Paper Publication
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==Structure of Calcineurin in complex with NHE1 peptide==
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<StructureSection load='6nuf' size='340' side='right'caption='[[6nuf]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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Authors: Wang, X., Page, R., Peti, W.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6nuf]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NUF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NUF FirstGlance]. <br>
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Description: Structure of Calcineurin in complex with NHE1 peptide
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nuf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nuf OCA], [http://pdbe.org/6nuf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nuf RCSB], [http://www.ebi.ac.uk/pdbsum/6nuf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nuf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PP2BA_HUMAN PP2BA_HUMAN]] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.<ref>PMID:15671020</ref> <ref>PMID:18838687</ref> [[http://www.uniprot.org/uniprot/SL9A1_HUMAN SL9A1_HUMAN]] Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.<ref>PMID:8901634</ref> <ref>PMID:11350981</ref> <ref>PMID:15035633</ref> [[http://www.uniprot.org/uniprot/CANB1_HUMAN CANB1_HUMAN]] Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Phosphoprotein phosphatase]]
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[[Category: Page, R]]
[[Category: Peti, W]]
[[Category: Peti, W]]
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[[Category: Page, R]]
 
[[Category: Wang, X]]
[[Category: Wang, X]]
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[[Category: Complex]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-calcium binding protein complex]]
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[[Category: Ser/thr phosphatase]]

Revision as of 05:55, 3 July 2019

Structure of Calcineurin in complex with NHE1 peptide

PDB ID 6nuf

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