6e0k
From Proteopedia
(Difference between revisions)
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==Structure of Rhodothermus marinus CdnE c-UMP-AMP synthase== | ==Structure of Rhodothermus marinus CdnE c-UMP-AMP synthase== | ||
| - | <StructureSection load='6e0k' size='340' side='right' caption='[[6e0k]], [[Resolution|resolution]] 1.60Å' scene=''> | + | <StructureSection load='6e0k' size='340' side='right' caption='[[6e0k]], [[Resolution|resolution]] 1.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6e0k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E0K FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6e0k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodothermus_marinus_sg0.5jp17-172 Rhodothermus marinus sg0.5jp17-172]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E0K FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e0k OCA], [http://pdbe.org/6e0k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e0k RCSB], [http://www.ebi.ac.uk/pdbsum/6e0k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e0k ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rhom172_2837 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=762570 Rhodothermus marinus SG0.5JP17-172])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e0k OCA], [http://pdbe.org/6e0k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e0k RCSB], [http://www.ebi.ac.uk/pdbsum/6e0k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e0k ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Cyclic dinucleotides (CDNs) have central roles in bacterial homeostasis and virulence by acting as nucleotide second messengers. Bacterial CDNs also elicit immune responses during infection when they are detected by pattern-recognition receptors in animal cells. Here we perform a systematic biochemical screen for bacterial signalling nucleotides and discover a large family of cGAS/DncV-like nucleotidyltransferases (CD-NTases) that use both purine and pyrimidine nucleotides to synthesize a diverse range of CDNs. A series of crystal structures establish CD-NTases as a structurally conserved family and reveal key contacts in the enzyme active-site lid that direct purine or pyrimidine selection. CD-NTase products are not restricted to CDNs and also include an unexpected class of cyclic trinucleotide compounds. Biochemical and cellular analyses of CD-NTase signalling nucleotides demonstrate that these cyclic di- and trinucleotides activate distinct host receptors and thus may modulate the interaction of both pathogens and commensal microbiota with their animal and plant hosts. | ||
| + | |||
| + | Bacterial cGAS-like enzymes synthesize diverse nucleotide signals.,Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ, Kranzusch PJ Nature. 2019 Feb 20. pii: 10.1038/s41586-019-0953-5. doi:, 10.1038/s41586-019-0953-5. PMID:30787435<ref>PMID:30787435</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6e0k" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Rhodothermus marinus sg0 5jp17-172]] | ||
[[Category: Eaglesham, J B]] | [[Category: Eaglesham, J B]] | ||
[[Category: King, D S]] | [[Category: King, D S]] | ||
Revision as of 08:20, 6 March 2019
Structure of Rhodothermus marinus CdnE c-UMP-AMP synthase
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