This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6b95
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Multiconformer model of K197C PTP1B tethered to compound 2 at 100 K== | ==Multiconformer model of K197C PTP1B tethered to compound 2 at 100 K== | ||
| - | <StructureSection load='6b95' size='340' side='right' caption='[[6b95]], [[Resolution|resolution]] 1.95Å' scene=''> | + | <StructureSection load='6b95' size='340' side='right'caption='[[6b95]], [[Resolution|resolution]] 1.95Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6b95]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6b95]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B95 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D0P:N-(2,4-difluoro-4-hydroxy[1,1-biphenyl]-3-yl)-2-sulfanylacetamide'>D0P</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D0P:N-(2,4-difluoro-4-hydroxy[1,1-biphenyl]-3-yl)-2-sulfanylacetamide'>D0P</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6b90|6b90]], [[6b8e|6b8e]], [[6b8t|6b8t]], [[6b8x|6b8x]], [[6b8z|6b8z]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6b90|6b90]], [[6b8e|6b8e]], [[6b8t|6b8t]], [[6b8x|6b8x]], [[6b8z|6b8z]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPN1, PTP1B ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPN1, PTP1B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b95 OCA], [https://pdbe.org/6b95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b95 RCSB], [https://www.ebi.ac.uk/pdbsum/6b95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b95 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 23: | Line 23: | ||
==See Also== | ==See Also== | ||
| - | *[[Tyrosine phosphatase|Tyrosine phosphatase]] | + | *[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
| Line 29: | Line 29: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Protein-tyrosine-phosphatase]] | [[Category: Protein-tyrosine-phosphatase]] | ||
[[Category: Biel, J T]] | [[Category: Biel, J T]] | ||
Current revision
Multiconformer model of K197C PTP1B tethered to compound 2 at 100 K
| |||||||||||
Categories: Human | Large Structures | Protein-tyrosine-phosphatase | Biel, J T | Brandao-Neto, J | Delft, F von | Fraser, J S | Hill, Z B | Kang, E | Keedy, D A | Rettenmaier, T J | Wells, J A | Allostery | Covalent ligand | Enzyme | Multiconformer | Multitemperature | Protein tyrosine phosphatase | Protein tyrosine phosphatase 1b | Ptp | Ptp1b | Signaling protein | Tethering
