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Diphtheria toxin

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== Structural highlights ==
== Structural highlights ==
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<scene name='59/592684/Cv/17'>The biological assembly of Diphtheria toxin is dimer</scene>. DT is proteolitically cleaved into 2 fragments. <scene name='59/592684/Cv/7'>Fragment A contains the catalytic domain (C)</scene> and <scene name='59/592684/Cv/8'>fragment B</scene> contains the <scene name='59/592684/Cv/9'>transmembrane (T)</scene> and <scene name='59/592684/Cv/10'>receptor-binding (R)</scene> domains. <scene name='59/592684/Cv/15'>DT active site</scene> is located in a cleft in the C domain.<ref>PMID:7833807</ref> Water molecules are shown as red spheres. The 2 monomers of DT interact by domain swapping to form a <scene name='59/592684/Cv/16'>compact, globular dimer structure</scene>.
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<scene name='59/592684/Cv/17'>The biological assembly of Diphtheria toxin is dimer</scene>. DT is proteolitically cleaved into 2 fragments. <scene name='59/592684/Cv/7'>Fragment A contains the catalytic domain (C)</scene> and <scene name='59/592684/Cv/8'>fragment B</scene> contains the <scene name='59/592684/Cv/9'>transmembrane (T)</scene> and <scene name='59/592684/Cv/10'>receptor-binding (R)</scene> domains. <scene name='59/592684/Cv/19'>DT active site</scene> is located in a cleft in the C domain.<ref>PMID:7833807</ref> Water molecules are shown as red spheres. The 2 monomers of DT interact by domain swapping to form a <scene name='59/592684/Cv/16'>compact, globular dimer structure</scene>.
</StructureSection>
</StructureSection>

Revision as of 15:47, 17 February 2020

Structure of diphtheria toxin complex with adenylyl-UMP (PDB code 1ddt).

Drag the structure with the mouse to rotate

3D structures of diphtheria toxin

Updated on 17-February-2020

References

  1. ↑ Pappenheimer AM Jr. Diphtheria toxin. Annu Rev Biochem. 1977;46:69-94. PMID:20040 doi:http://dx.doi.org/10.1146/annurev.bi.46.070177.000441
  2. ↑ Bennett MJ, Choe S, Eisenberg D. Refined structure of dimeric diphtheria toxin at 2.0 A resolution. Protein Sci. 1994 Sep;3(9):1444-63. PMID:7833807

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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