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3x44

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==Crystal structure of O-ureido-L-serine-bound K43A mutant of O-ureido-L-serine synthase==
==Crystal structure of O-ureido-L-serine-bound K43A mutant of O-ureido-L-serine synthase==
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<StructureSection load='3x44' size='340' side='right' caption='[[3x44]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='3x44' size='340' side='right'caption='[[3x44]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3x44]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_lavendulae"_waksman_and_curtis_1916 "actinomyces lavendulae" waksman and curtis 1916]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X44 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3x44]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_lavendulae"_waksman_and_curtis_1916 "actinomyces lavendulae" waksman and curtis 1916]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3X44 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PUS:(E)-O-(CARBAMOYLAMINO)-N-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYLIDENE)-L-SERINE'>PUS</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PUS:(E)-O-(CARBAMOYLAMINO)-N-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYLIDENE)-L-SERINE'>PUS</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dcsD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1914 "Actinomyces lavendulae" Waksman and Curtis 1916])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dcsD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1914 "Actinomyces lavendulae" Waksman and Curtis 1916])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x44 OCA], [http://pdbe.org/3x44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3x44 RCSB], [http://www.ebi.ac.uk/pdbsum/3x44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3x44 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3x44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x44 OCA], [https://pdbe.org/3x44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3x44 RCSB], [https://www.ebi.ac.uk/pdbsum/3x44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3x44 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DCSD_STRLA DCSD_STRLA]] Involved in the biosynthesis of the antibiotic D-cycloserine (DCS), a cyclic structural analog of D-alanine, used as an antitubercular agent. Catalyzes the addition of hydroxyurea on O-acetyl-L-serine (OAS) to yield O-ureido-L-serine. It prefers sulfide as the second substrate, followed by hydroxyurea, L-homocysteine, and thiosulfate.<ref>PMID:20086163</ref> <ref>PMID:23529730</ref>
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[[https://www.uniprot.org/uniprot/DCSD_STRLA DCSD_STRLA]] Involved in the biosynthesis of the antibiotic D-cycloserine (DCS), a cyclic structural analog of D-alanine, used as an antitubercular agent. Catalyzes the addition of hydroxyurea on O-acetyl-L-serine (OAS) to yield O-ureido-L-serine. It prefers sulfide as the second substrate, followed by hydroxyurea, L-homocysteine, and thiosulfate.<ref>PMID:20086163</ref> <ref>PMID:23529730</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Actinomyces lavendulae waksman and curtis 1916]]
[[Category: Actinomyces lavendulae waksman and curtis 1916]]
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[[Category: Large Structures]]
[[Category: Matoba, Y]]
[[Category: Matoba, Y]]
[[Category: Oda, K]]
[[Category: Oda, K]]

Revision as of 05:40, 10 August 2022

Crystal structure of O-ureido-L-serine-bound K43A mutant of O-ureido-L-serine synthase

PDB ID 3x44

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