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3x43
From Proteopedia
(Difference between revisions)
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==Crystal structure of O-ureido-L-serine synthase== | ==Crystal structure of O-ureido-L-serine synthase== | ||
| - | <StructureSection load='3x43' size='340' side='right' caption='[[3x43]], [[Resolution|resolution]] 2.25Å' scene=''> | + | <StructureSection load='3x43' size='340' side='right'caption='[[3x43]], [[Resolution|resolution]] 2.25Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3x43]] is a 8 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3x43]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_lavendulae"_waksman_and_curtis_1916 "actinomyces lavendulae" waksman and curtis 1916]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3X43 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dcsD ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dcsD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1914 "Actinomyces lavendulae" Waksman and Curtis 1916])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3x43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x43 OCA], [https://pdbe.org/3x43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3x43 RCSB], [https://www.ebi.ac.uk/pdbsum/3x43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3x43 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/DCSD_STRLA DCSD_STRLA]] Involved in the biosynthesis of the antibiotic D-cycloserine (DCS), a cyclic structural analog of D-alanine, used as an antitubercular agent. Catalyzes the addition of hydroxyurea on O-acetyl-L-serine (OAS) to yield O-ureido-L-serine. It prefers sulfide as the second substrate, followed by hydroxyurea, L-homocysteine, and thiosulfate.<ref>PMID:20086163</ref> <ref>PMID:23529730</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Actinomyces lavendulae waksman and curtis 1916]] | [[Category: Actinomyces lavendulae waksman and curtis 1916]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Matoba, Y]] | [[Category: Matoba, Y]] | ||
[[Category: Oda, K]] | [[Category: Oda, K]] | ||
Revision as of 05:40, 10 August 2022
Crystal structure of O-ureido-L-serine synthase
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