Adaptin

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</StructureSection>
</StructureSection>
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===3D structures of adaptin===
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*AP-α-2
 
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**[[1b9k]], [[1qts]] – mAP appendage domain – mouse<br />
 
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**[[1qtp]] – mAP appendage domain (mutant)<br />
 
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**[[1ky6]], [[1kyd]] – mAP appendage domain + epsin peptide<br />
 
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**[[1ky7]] – mAP appendage domain + amphiphysin peptide<br />
 
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**[[1kyf]], [[1kyu]] – mAP appendage domain + eps15 peptide<br />
 
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**[[1w80]], [[2vj0]] – mAP appendage domain + synaptojanin peptide<br />
 
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**[[3hs8]] – mAP appendage domain + intersectin peptide<br />
 
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*AP-β
 
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**[[1e42]] – hAP-1 appendage domain - human<br />
 
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**[[2g30]] – hAP-1 appendage domain + ARH peptide<br />
 
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**[[3h1z]] – hAP-1 appendage domain + PTDINSPKI-γ peptide<br />
 
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**[[3hs9]] – hAP-1 appendage domain + intersectin peptide<br />
 
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**[[2iv9]] – hAP-2 appendage domain + eps15 peptide<br />
 
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**[[2iv8]] – hAP-2 appendage domain + B-arrestin peptide<br />
 
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**[[1mj7]] – hAP-4 appendage domain <br />
 
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*AP-γ
 
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**[[1iu1]] – hAP-1 ear domain<br />
 
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**[[1gyu]], [[2a7b]] – mAP-1 appendage domain <br />
 
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**[[1gyv]], [[1gyw]], [[3zy7]] – mAP-1 appendage domain (mutant)<br />
 
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**[[2e9g]], [[4bcx]] – hAP-2 ear domain<br />
 
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**[[2ymt]] – hAP-2 ear domain + peptide<br />
 
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**[[3zhf]] – hAP-2 ear domain + large envelope protein peptide<br />
 
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*AP-δ-1
 
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**[[4afi]] – hAP-1/vesicle-associated membrane protein 7<br />
 
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*AP-μ
 
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**[[3h85]] – rAP-1 appendage domain + PTDINSPKIγ peptide<br />
 
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**[[4emz]], [[4en2]] – mAP-1 sorting motif recognition domain + nef + MHC-I<br />
 
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**[[2bp5]] – rAP-2 + purinoceptor peptide<br />
 
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**[[1bw8]], [[1i31]] – rAP-2 C-terminal + EGFR peptide<br />
 
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**[[1bxx]] – rAP-2 C-terminal + TGN38 peptide<br />
 
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**[[1hes]] – rAP-2 C-terminal + selectin peptide<br />
 
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**[[5c7z]], [[5fpi]] – rAP-2 C terminal + integrin peptide<br />
 
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**[[2pr9]] – rAP-2 C-terminal + GABA receptor peptide<br />
 
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**[[5wrm]], [[5wrl]], [[5wrk]] – rAP-2 C-terminal + insulin receptor substrate peptide <br />
 
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**[[4ikn]] – rAP-3 + TGN38 sorting peptide <br />
 
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**[[3l81]], [[4mdr]] – hAP-4 + amyloid beta-A4 peptide <br />
 
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**[[6bnt]] – hAP-2 C-terminal + insulin receptor substrate peptide <br />
 
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*AP-α2 + AP-σ
 
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**[[4nee]] – rAP-2 + HIV-1 NEF <br />
 
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*AP-α2 + AP-β + AP-σ
 
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**[[4uqi]] – rAP-2 + VPU <br />
 
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*AP-α + AP-β + AP-μ + AP-σ
 
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**[[2vgl]] – rAPα-2 + APβ-1 + APμ-1 + APσ-1 <br />
 
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**[[4uqi]] – rAPα-2 + APβ-2 + APμ-2 + APσ-1 <br />
 
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**[[2jkr]], [[2jkt]] – mAPα-2 + APβ-1 + APμ-1 + APσ-1 + CD4 peptide<br />
 
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**[[2xa7]] – rAPα-2 + APβ + APμ + APσ + cargo peptide<br />
 
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*AP-β-1 + AP-γ-1 + AP-μ-1 + AP-σ-3
 
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**[[6dff]], [[6d84]], [[6d83]], [[6cri]], [[6cm9]] – hAPβ-1 + APμ-1 + APσ-3 + ARF1 + tetherin-NEF – Cryo EM <br />
 
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*AP-γ + AP-β + AP-μ + AP-σ
 
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**[[1w63]] – mAP-1 <br />
 
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**[[4hmy]] – mAP-1 + ADP-ribosylation factor<br />
 
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**[[4p6z]] – mAP-1 + VPU + bone marrow stromal antigen<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:58, 28 February 2019

Structure of Adaptin core: AP-α-2 (cyan), AP-β-1 (magenta), AP-μ-1 (green), AP-σ-1 (olive) complex with inositole hexakisphosphate (PDB entry 2vgl)

Drag the structure with the mouse to rotate


References

  1. 1.0 1.1 Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ. Molecular architecture and functional model of the endocytic AP2 complex. Cell. 2002 May 17;109(4):523-35. PMID:12086608

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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