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1a9l

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[[Image:1a9l.jpg|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a9l OCA], [http://www.ebi.ac.uk/pdbsum/1a9l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a9l RCSB]</span>
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'''SOLUTION STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, NMR, 12 STRUCTURES'''
'''SOLUTION STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, NMR, 12 STRUCTURES'''
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[[Category: Ribonucleic acid]]
[[Category: Ribonucleic acid]]
[[Category: Rna structure]]
[[Category: Rna structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:00:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat Apr 5 19:22:30 2008''
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Revision as of 07:00, 2 May 2008

Image:1a9l.jpg

Template:STRUCTURE 1a9l

SOLUTION STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, NMR, 12 STRUCTURES


Overview

The structure of the bulge-helix-bulge motif that constitutes the intron/exon splice site in H. volcanii pre-tRNATrp has been determined by NMR spectroscopy. The conformations of the two 3 nt bulges, where the pre-tRNA is cleaved, are stabilized by stacking interactions between bulge nucleotides and bases in the adjacent Watson-Crick helices and by a network of backbone hydrogen bonds. Both bulges are presented on the same minor groove face of the central 4 bp helix, and the overall structure has approximate two-fold symmetry, which makes it well-suited for attack by archaeal splicing endonucleases, which are symmetric dimers.

About this Structure

Full crystallographic information is available from OCA.

Reference

Solution structure of a substrate for the archaeal pre-tRNA splicing endonucleases: the bulge-helix-bulge motif., Diener JL, Moore PB, Mol Cell. 1998 May;1(6):883-94. PMID:9660971 Page seeded by OCA on Fri May 2 10:00:58 2008

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