Agglutinin
From Proteopedia
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<StructureSection load='' size='450' side='right' caption='Agglutinin complex with polysaccharide of α- and β-mannose, imidazole and Na+ ion (purple) (PDB code [[4gk9]])' scene='74/749490/Cv/1'> | <StructureSection load='' size='450' side='right' caption='Agglutinin complex with polysaccharide of α- and β-mannose, imidazole and Na+ ion (purple) (PDB code [[4gk9]])' scene='74/749490/Cv/1'> | ||
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== Function == | == Function == | ||
'''Agglutinin'''s or '''galactose-inding lectin''' (AGG) are sugar-binding lectins which cause particles to change from fluid state to thickened-mass state. '''Agglutinin isolectin''' or '''wheat germ agglutinin''' is a plant protein that binds specifically to sugars expressed by human gastrointestinal epithelial and immune cells<ref>PMID:19332085</ref>. | '''Agglutinin'''s or '''galactose-inding lectin''' (AGG) are sugar-binding lectins which cause particles to change from fluid state to thickened-mass state. '''Agglutinin isolectin''' or '''wheat germ agglutinin''' is a plant protein that binds specifically to sugars expressed by human gastrointestinal epithelial and immune cells<ref>PMID:19332085</ref>. | ||
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of agglutinin == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Agglutinin | ||
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| - | **[[4r6r]], [[1ku8]] – jfAGG alpha+ beta-3 chains – jack fruit <br /> | ||
| - | **[[5d5g]] – AGG - tuber <br /> | ||
| - | **[[4uri]], [[1fny]] – RpAGG – ''Robinia pseudoacacia'' <br /> | ||
| - | **[[4g9m]] – RsAGG – ''Rhizoctonia solani''<br /> | ||
| - | **[[4gu8]] – BoAGG – ''Burkholderia oklahomensis''<br /> | ||
| - | **[[4fbo]] – AGG – ''Pseudomonas fluorescens'' <br /> | ||
| - | **[[2x2s]] – SsAGG – ''Sclerotinia sclerotiorum'' <br /> | ||
| - | **[[4fbr]] – MxAGG – ''Myxococcus xanthus'' <br /> | ||
| - | **[[3s5v]], [[3s60]] – OaAGG – ''Oscillatoria agardhi'' <br /> | ||
| - | **[[3lly]] – MpAGG alpha+ beta-2 chains – ''Maclura pomifera'' <br /> | ||
| - | **[[2ce6]] – HpAGG – ''Helix pomatia''<br /> | ||
| - | **[[1ouw]] – AGG – hedge bindweed<br /> | ||
| - | **[[1dlp]], [[1b2p]] – AGG – ''Scilla campanulata''<br /> | ||
| - | **[[1c3k]] – HtAGG – ''Helianthus tuberosus''<br /> | ||
| - | **[[1jly]] – AcAGG – ''Amaranthus caudatus''<br /> | ||
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| - | * Agglutinin complex with polysaccharide | ||
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| - | **[[5j51]], [[5jm1]], [[4r6n]], [[4r6o]], [[4r6p]], [[4r6q]], [[4r6r]], [[4akc]], [[5j50]], [[5j4x]], [[5j4t]] – jfAGG alpha+ beta-3 chains + polysaccharide <br /> | ||
| - | **[[5jm1]] – jfAGG alpha+ beta-3 chains + trisaccharide <br /> | ||
| - | **[[1g9f]], [[2sba]], [[1sbd]], [[1sbe]], [[1sbf]] – soAGG + polysaccharide - soybean<br /> | ||
| - | **[[1jlx]] – AcAGG + polysaccharide <br /> | ||
| - | **[[4gk9]] – BoAGG + polysaccharide <br /> | ||
| - | **[[4fbv]] – MxAGG + polysaccharide <br /> | ||
| - | **[[3s5x]] – OaAGG + polysaccharide <br /> | ||
| - | **[[3llz]] – MpAGG + polysaccharide <br /> | ||
| - | **[[1c3m]], [[1c3n]] – HtAGG + polysaccharide <br /> | ||
| - | **[[1cr7]], [[1ciw]], [[2tep]], [[1bzw]], [[2pel]], [[2dv9]], [[2dva]], [[2dvb]], [[2dvd]], [[2dvf]], [[2dvg]] – pAGG + polysaccharide - peanut<br /> | ||
| - | **[[2x2t]] – SsAGG + polysaccharide <br /> | ||
| - | **[[1jot]] – AGG + polysaccharide – osage orange<br /> | ||
| - | **[[3ef2]], [[2iho]] – MoAGG + polysaccharide – ''Marasmius oreades''<br /> | ||
| - | **[[3c9z]], [[3ca0]], [[3ca1]], [[3ca3]], [[3ca4]], [[3ca5]], [[3ca6]], [[3cah]] – AGG II + polysaccharide – ''Sambucus nigra''<br /> | ||
| - | **[[2zmk]], [[2zml]], [[2zmn]], [[2e51]], [[2e53]], [[2e7q]], [[2e7t]], [[1f9k]], [[1wbl]] – GbAGG + polysaccharide – Goa bean<br /> | ||
| - | **[[1jpc]], [[1niv]] – snAGG + polysaccharide – snowdrop<br /> | ||
| - | **[[2zr1]] – IlAGG alpha+ beta chains + polysaccharide – Indian licorice<br /> | ||
| - | **[[1ugy]], [[1uh1]] – jfAGG alpha+ beta-3 chains + polysaccharide <br /> | ||
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| - | * Agglutinin complex with monosaccharide | ||
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| - | **[[4ak4]], [[4akb]], [[1jac]] – jfAGG alpha+ beta-3 chains + saccharide <br /> | ||
| - | **[[5kxb]] – wiAGG + GalNAc - wisteria <br /> | ||
| - | **[[5kxc]], [[5kxd]], [[5kxe]] – wiAGG + polysaccharide <br /> | ||
| - | **[[5d9z]] – AGG + mannose - taro <br /> | ||
| - | **[[3dzw]], [[1npl]] – AGG + mannose – daffodil <br /> | ||
| - | **[[4q56]] – AGG + saccharide – ''Helix aspersa''<br /> | ||
| - | **[[4g9n]] – RsAGG + saccharide <br /> | ||
| - | **[[2d3s]] – GbAGG + saccharide + antigen <br /> | ||
| - | **[[2dtw]], [[2dty]], [[2du0]], [[2du1]], [[1fay]], [[1wbf]] – GbAGG + saccharide <br /> | ||
| - | **[[2cgz]], [[2cgy]] – HpAGG + saccharide + antigen <br /> | ||
| - | **[[2ccv]] – HpAGG + saccharide <br /> | ||
| - | **[[1fnz]] – RpAGG + saccharide <br /> | ||
| - | **[[1qf3]] – pAGG + saccharide <br /> | ||
| - | **[[2cgz]] – AGG + saccharide – ''Bowringia milbraedii''<br /> | ||
| - | **[[1rzo]] – AGG + saccharide – ''Ricinus communis''<br /> | ||
| - | **[[1toq]], [[1tp8]] – AGG + saccharide – ''Artocarpus hirsuta''<br /> | ||
| - | **[[1msa]] – snAGG + saccharide <br /> | ||
| - | **[[2q3n]] – IlAGG alpha+ beta chains + saccharide <br /> | ||
| - | **[[1kj1]], [[1bwu]] – AGG I II chains + saccharide - garlic<br /> | ||
| - | **[[3lm1]] – MpAGG alpha+ beta-2 chains + saccharide <br /> | ||
| - | **[[1ws4]], [[1ws5]], [[1ugw]], [[1uh0]], [[1kuj]] – jfAGG alpha+ beta-3 chains + saccharide <br /> | ||
| - | **[[1ugx]], [[1m26]] – jfAGG alpha+ beta-3 chains + saccharide + antigen<br /> | ||
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| - | *Agglutinin complex with other compounds | ||
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| - | **[[5d61]], [[5d62]], [[5d63]] – MoAGG + peptide inhibitor <br /> | ||
| - | **[[5mu9]] – MoAGG + guanidine derivative <br /> | ||
| - | **[[4d69]] – soAGG + peptide <br /> | ||
| - | **[[1pxd]] – jfAGG alpha+ beta-3 chains + porphyrin derivative <br /> | ||
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| - | *Agglutinin isolectin | ||
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| - | **[[7wga]], [[9wga]] – wgAGG 1 – wheat germ <br /> | ||
| - | **[[4aml]] – wgAGG 1 + glycosylurethan <br /> | ||
| - | **[[2x3t]], [[2cwg]] – wgAGG 1 + glycopeptide <br /> | ||
| - | **[[2uvo]] – wgAGG 1 + NAG <br /> | ||
| - | **[[1wgc]], [[2wgc]] – wgAGG 1+ polysaccharide <br /> | ||
| - | **[[1en2]], [[1enm]] – gnAGG 1 + NAG – great nettle <br /> | ||
| - | **[[1wgt]] – wgAGG 3 <br /> | ||
| - | **[[2x52]] – wgAGG 3 + pyranose derivative <br /> | ||
| - | **[[1k7t]], [[1k7u]], [[1k7v]] – wgAGG 3 + polysaccharide <br /> | ||
| - | **[[1iqb]], [[1eis]], [[1ehd]], [[1ehh]] – gnAGG 6 <br /> | ||
| - | **[[1ehh]] – gnAGG 6+ polysaccharide <br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Dalla Pellegrina C, Perbellini O, Scupoli MT, Tomelleri C, Zanetti C, Zoccatelli G, Fusi M, Peruffo A, Rizzi C, Chignola R. Effects of wheat germ agglutinin on human gastrointestinal epithelium: insights from an experimental model of immune/epithelial cell interaction. Toxicol Appl Pharmacol. 2009 Jun 1;237(2):146-53. doi:, 10.1016/j.taap.2009.03.012. Epub 2009 Mar 28. PMID:19332085 doi:http://dx.doi.org/10.1016/j.taap.2009.03.012
- ↑ Swiecicki PL, Hegerova LT, Gertz MA. Cold agglutinin disease. Blood. 2013 Aug 15;122(7):1114-21. doi: 10.1182/blood-2013-02-474437. Epub 2013, Jun 11. PMID:23757733 doi:http://dx.doi.org/10.1182/blood-2013-02-474437
- ↑ Whitley MJ, Furey W, Kollipara S, Gronenborn AM. Burkholderia oklahomensis agglutinin is a canonical two-domain OAA-family lectin: structures, carbohydrate binding and anti-HIV activity. FEBS J. 2013 May;280(9):2056-67. doi: 10.1111/febs.12229. Epub 2013 Apr 2. PMID:23480609 doi:10.1111/febs.12229
