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Aldehyde dehydrogenase
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(Difference between revisions)
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of Aldehyde dehydrogenase == | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *ALDH class 1 | ||
| - | |||
| - | **[[3fx4]] – ALDH1 + NADP + inhibitor – pig<BR /> | ||
| - | **[[1bxs]] – sALDH1 + NAD - sheep<br /> | ||
| - | **[[5abm]] - sALDH1 + NAD derivative<br /> | ||
| - | **[[5ac0]] - sALDH1 + NAD + duocarmycin analog<br /> | ||
| - | **[[5ac1]], [[5ac2]] - sALDH1 + duocarmycin analog<br /> | ||
| - | **[[1o9j]] – ALDH1 + NAD – Elephant shrew<br /> | ||
| - | **[[3rhj]], [[3rhl]], [[3rho]], [[3rhp]], [[3rhq]], [[3rhr]] – rALDH1 C- terminal (mutant) + NADP – rat<br /> | ||
| - | **[[3rhm]] - rALDH1 C- terminal<br /> | ||
| - | **[[1hso]] – hALDH1 α subunit + Zn + NAD - human<br /> | ||
| - | **[[4wj9]] - hALDH1 (mutant) <br /> | ||
| - | **[[4wpn]] - hALDH1 + inhibitor<br /> | ||
| - | **[[4wp7]] - hALDH1 (mutant) + inhibitor<br /> | ||
| - | **[[4wb9]] - hALDH1 + NAD derivative <br /> | ||
| - | **[[4x4l]] - hALDH1 + NAD derivative + inhibitor<br /> | ||
| - | **[[1ht0]] – hALDH1 γ subunit (mutant) + Zn + NAD | ||
| - | |||
| - | *ALDH class 1 A (retinal dehydrogenase) | ||
| - | |||
| - | **[[5l2m]], [[5l2n]], [[5l2o]] – hRALDH1 + inhibitor<br /> | ||
| - | **[[5tei]] – hRALDH1 + NAD + inhibitor<br /> | ||
| - | **[[6alj]], [[6b5g]], [[6b5h]], [[6b5i]] – hRALDH2 + NAD + inhibitor<br /> | ||
| - | **[[5fhz]] – hRALDH3 + NAD + retinol<br /> | ||
| - | |||
| - | *ALDH class 2 | ||
| - | |||
| - | **[[3n80]], [[1o05]], [[4kwf]] – hALDH2 residues 18-517<BR /> | ||
| - | **[[3n81]], [[2onn]], [[2ono]], [[1zum]] – hALDH2 residues 18-517 (mutant) <BR /> | ||
| - | **[[1ag8]] – bALDH NAD binding domain - bovine | ||
| - | |||
| - | *ALDH2 binary complex | ||
| - | |||
| - | **[[3inj]], [[3inl]], [[4kwg]] - hALDH2 residues 18-517 + agonist<BR /> | ||
| - | **[[2vle]] - hALDH2 residues 24-517 + daidzin<BR /> | ||
| - | **[[1nzx]], [[1nzz]], [[1o00]], [[1o02]], [[1cw3]], [[4x2q]] - hALDH2 residues 18-517 + NAD<BR /> | ||
| - | **[[3n82]], [[3n83]], [[2onm]], [[2onp]], [[1nzw]], [[1o04]] – hALDH2 residues 18-517 (mutant) + NADH<BR /> | ||
| - | **[[3sz9]] - hALDH2 residues 18-517 + inhibitor<br /> | ||
| - | **[[1a4z]] – bALDH2 NAD-binding domain + NAD<BR /> | ||
| - | **[[1bi9]] – rALDH2 + NAD<br /> | ||
| - | **[[4pxl]] – mALDH2 + NAD - maize<br /> | ||
| - | **[[4pz2]] – mALDH6 + NAD <br /> | ||
| - | **[[6d97]] – mALDH12 + NAD <br /> | ||
| - | |||
| - | *ALDH2 ternary complex | ||
| - | |||
| - | **[[1o01]] - hALDH2 residues 18-517 + NADH + aldehyde<br /> | ||
| - | **[[4fqf]] - hALDH2 residues 18-517 + NAD + NO2<br /> | ||
| - | **[[4fr8]] - hALDH2 residues 18-517 (mutant) + NAD + ADP + nitroglycerin<br /> | ||
| - | **[[5l13]] – hALDH2 + inhibitor<br /> | ||
| - | |||
| - | *ALDH class 3 | ||
| - | |||
| - | **[[1ad3]] – rALDH3<br /> | ||
| - | **[[3sza]] - hALDH3A1<br /> | ||
| - | **[[3szb]], [[4l1o]], [[4l2o]] – hALDH3A1 + inhibitor<br /> | ||
| - | **[[4h80]] - hALDH3A1 (mutant) + inhibitor<br /> | ||
| - | **[[4qgk]] – hALDH3A2 + ligand<br /> | ||
| - | **[[5myp]] – TbALDH – ''Trypanosoma brucei''<br /> | ||
| - | **[[5nno]] – TbALDH + NAD + inhibitor <br /> | ||
| - | |||
| - | *NAD-dependent ALDH | ||
| - | |||
| - | **[[2w8n]], [[2w8o]], [[2w8r]] – Succinate–semi-hALDH family 5<BR /> | ||
| - | **[[2w8p]] - Succinate–semi-hALDH family 5 (mutant) <BR /> | ||
| - | **[[3r31]] – Betaine-ALDH – ''Agrobacterium tumefaciens''<BR /> | ||
| - | **[[4mpb]], [[4nu9]], [[4q92]], [[4qto]] - Betaine-SaALDH – ''Staphylococcus aureus''<BR /> | ||
| - | **[[4qje]] - Betaine-SaALDH (mutant)<br /> | ||
| - | **[[4zxu]], [[4zwl]] - Betaine-SaALDH (mutant) + NAD<br /> | ||
| - | **[[4cbb]], [[6bpg]] - Betaine-PaALDH - ''Pseudomonas aeruginosa''<br /> | ||
| - | **[[6bjp]] - Betaine-PaALDH (mutant)<br /> | ||
| - | **[[1a4s]] - Betaine-cALDH - cod<BR /> | ||
| - | **[[3vos]], [[3tz6]], [[3vos]] – Aspartate-semi-MtALDH<BR /> | ||
| - | **[[2cq8]] - Formyltetrahydrofolate-hALDH PP-binding domain - NMR<BR /> | ||
| - | **[[2nac]] – Formate-PsALDH<BR /> | ||
| - | **[[3i44]] – ALDH – ''Bartonella henselae''<BR /> | ||
| - | **[[3ek1]] – ALDH – ''Brucella melitensis''<br /> | ||
| - | **[[3ros]] – ALDH – ''Lactobacillus acidophilus''<br /> | ||
| - | **[[3r64]] – ALDH – ''Corynebacterium glutamicum''<br /> | ||
| - | **[[3rhe]] – Benzaldehyde-ALDH – ''Legionella pneumophila''<br /> | ||
| - | **[[3u4j]], [[4i3t]] – SmALDH – ''Sinorhizobium meliloti''<br /> | ||
| - | **[[5dru]] - CpALDH – ''Clostridium phytofermentans''<br /> | ||
| - | **[[4qf6]], [[5gt6]] – BcALDH – ''Bacillus cereus''<br /> | ||
| - | **[[4qet]] – BcALDH (mutant)<br /> | ||
| - | **[[5uju]] - BmALDH – ''Burkholderia multivorans''<br /> | ||
| - | **[[6fk3]], [[6fkv]], [[6fjv]] - TtALDH – ''Thermus thermophilus''<br /> | ||
| - | |||
| - | *NAD-dependent ALDH binary complexes | ||
| - | |||
| - | **[[2w8q]] - Succinate–semi-hALDH family 5 + succinic acid<BR /> | ||
| - | **[[4mpy]], [[4nea]] - Betaine-SaALDH + NAD<BR /> | ||
| - | **[[4qn2]], [[5ez4]], [[5eyu]], [[5dib]] - Betaine-SaALDH (mutant) + NAD<br /> | ||
| - | **[[1bpw]] - Betaine-cALDH + NAD<BR /> | ||
| - | **[[4zvw]], [[4zvx]] - Aminoadipate-semi-hALDH family 7<br /> | ||
| - | **[[2j6l]], [[4zvy]] – Aminoadipate-semi-hALDH family 7 + NAD<BR /> | ||
| - | **[[4x0u]] - Aminoadipate-semi-hALDH family 7+ inhibitor<br /> | ||
| - | **[[4zuk]] - Aminoadipate-semi-hALDH family 7+ NAD<br /> | ||
| - | **[[4zul]] - Aminoadipate-semi-hALDH family 7+ α-aminoadipate<br /> | ||
| - | **[[2cfi]] - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin<BR /> | ||
| - | **[[2nad]] - Formate-PaALDH + NAD <BR /> | ||
| - | **[[3l4p]], [[1sij]] – ALDH + AsO3 – ''Desulfovibrio gigas''<br /> | ||
| - | **[[4a0m]], [[4v37]] – spALDH + NAD – spinach<br /> | ||
| - | **[[5a2d]], [[4v3f]] – spALDH + choline<br /> | ||
| - | **[[3iwk]] – amino-ALDH + NAD – pea<br /> | ||
| - | **[[3ju8]] - Succinylglutamic–semi-PaALDH + NAD <br /> | ||
| - | **[[4caz]] - Betaine-PaALDH + NAD derivative<br /> | ||
| - | **[[4c3s]] - CpALDH + NAD <br /> | ||
| - | **[[5dbv]] - CpALDH + CoA <br /> | ||
| - | **[[4i3u]] – SmALDH + phosphonoacetaldehyde<br /> | ||
| - | **[[5gtk]] – BcALDH + NAD<br /> | ||
| - | **[[5jfl]] – RpALDH + NAD – ''Rhodopseudomonas palustris''<br /> | ||
| - | **[[6gvs]] – RpALDH + NADP <br /> | ||
| - | **[[5jfn]] – RpALDH + CoA <br /> | ||
| - | **[[6fku]] – TtALDH + NADP <br /> | ||
| - | |||
| - | *NAD-dependent ALDH ternary complexes | ||
| - | |||
| - | **[[2gsd]] – Formate-ALDH + NAD + azide – ''Moraxella''<BR /> | ||
| - | **[[1nvm]] – Acetaldehyde-PsALDH + 4-hydroxy-oxovalerate aldolase + NAD<BR /> | ||
| - | **[[1llu]] - PaALDH + NAD + alcohol<br /> | ||
| - | **[[4i3v]], [[4i3w]] – SmALDH + aldehyde derivative + NAD<br /> | ||
| - | **[[4i3x]] – SmALDH + phosphonoacete + NAD<br /> | ||
| - | **[[5jfm]] – RpALDH + CoA + propionyl-CoA<br /> | ||
| - | **[[4x0t]] - Aminoadipate-semi-hALDH family 7 + NAD+ inhibitor<br /> | ||
| - | |||
| - | *NADP-dependent ALDH | ||
| - | |||
| - | **[[3k2w]] - Betaine-ALDH – ''Pseudoalteromonas atlantica''<BR /> | ||
| - | **[[2hg2]], [[2opx]] – Lactaldehyde-EcALDH <BR /> | ||
| - | **[[2o2p]] – Formyltetrahydrofolate-rALDH C-terminal<br /> | ||
| - | **[[2y51]], [[2y52]], [[2y53]], [[2y5d]] – BxALDH (mutant) – ''Burkholderia xenovorans''<br /> | ||
| - | **[[4v6h]] - Succinate–semi-ALDH – ''Burkholderia pseudomallei''<br /> | ||
| - | **[[3rh9]] - Succinate–semi-ALDH – ''Marinobacter aquaeolei''<br /> | ||
| - | **[[3uw3]] - aspartate–semi-BtALDH – ''Burkholderia thailandensis''<br /> | ||
| - | **[[3v4c]] - SmALDH<br /> | ||
| - | **[[4gac]] – ALDH – mouse<br /> | ||
| - | **[[5eeb]] - PfALDH – ''Pyrobaculum ferrireducens''<br /> | ||
| - | |||
| - | *NADP-dependent ALDH binary complexes | ||
| - | |||
| - | **[[2wox]], [[2wme]], [[2xdr]], [[3zqa]] - Betaine-PaALDH + NADP<BR /> | ||
| - | **[[2ilu]] - Lactaldehyde-EcALDH + NADP<BR /> | ||
| - | **[[3rhd]] - Lactaldehyde-MjALDH + NADP - ''Methanocaldococcus jannaschii''<br /> | ||
| - | **[[2o2q]], [[2o2r]] - Formyltetrahydrofolate-rALDH C-terminal + NADP<BR /> | ||
| - | **[[3b4w]] - MtALDH + NADP – ''Mycobacterium tuberculosis''<BR /> | ||
| - | **[[1eyy]], [[1ez0]] – ALDH + NADP – ''Vibrio harveyi''<br /> | ||
| - | **[[3jz4]] - Succinate–semi-EcALDH + NADP<br /> | ||
| - | **[[3hsk]] - aspartate–semi-ALDH + NADP – ''Candida albicans''<br /> | ||
| - | **[[4h73]], [[4nmj]], [[4nmk]], [[5f2c]], [[5exf]], [[5euy]], [[5ekc]], [[5ek6]] - PfALDH + NADP <br /> | ||
| - | **[[5kf0]] - ALDH + NADP – ''Burkholderia vietnamiensis''<br /> | ||
| - | **[[5jry]] - BmALDH + NADP <br /> | ||
| - | **[[5j6b]] - BtALDH + NADP <br /> | ||
| - | **[[5gtl]] – BcALDH + NADP<br /> | ||
| - | |||
| - | *NADP-dependent ALDH ternary complexes | ||
| - | |||
| - | **[[2imp]] - Lactaldehyde-EcALDH + NADH + lactate<BR /> | ||
| - | **[[2vro]] – BxALDH + NADP + alcohol <br /> | ||
| - | |||
| - | *Indole-3-ALDH | ||
| - | |||
| - | **[[5iuu]] – PsIALDH – ''Pseudomonas syringae''<br /> | ||
| - | **[[5iuv]] – PsIALDH + NAD<br /> | ||
| - | **[[5iuw]] – PsIALDH + NAD + indole acetate<br /> | ||
| - | |||
| - | *NAD-dependent glyceraldehydes-3-phosphate dehydrogenase | ||
| - | |||
| - | **[[1vsu]] – CpGAPDH – ''Cryptosporidium parvum''<br /> | ||
| - | **[[1ywg]] – PfGAPDH – ''Plasmodium falciparum''<br /> | ||
| - | **[[2ep7]] – GAPDH – ''Aquifex aeolicus''<br /> | ||
| - | **[[2i5p]] – GAPDH – ''Kluyveromyces marxianus''<br /> | ||
| - | **[[1obf]] – GAPDH – ''Achromobacter xylosoxidans''<br /> | ||
| - | **[[1b7g]] – GAPDH – ''Sulfolobus solfataricus''<br /> | ||
| - | **[[2gd1]], [[3cmc]] – GsGAPDH – ''Geobacillus stearothermophilus''<br /> | ||
| - | **[[3e6a]] – OsGAPDH – ''Oryza sativa''<br /> | ||
| - | **[[4gpd]], [[1gpd]], [[1crw]] – GAPDH – lobster<br /> | ||
| - | **[[3l6o]], [[3lc7]] – SaGAPDH<br /> | ||
| - | **[[1dc3]], [[1dc5]], [[1s7c]] – EcGAPDH - ''Escherichia coli''<br /> | ||
| - | |||
| - | *''GAPDH binary complex'' | ||
| - | |||
| - | **[[1k3t]] - TcGAPDH + inhibitor<br /> | ||
| - | **[[3hja]] - GAPDH + NAD – ''Borellia burgdorferi''<br /> | ||
| - | **[[1vsv]], [[3cps]] - CpGAPDH + NAD<br /> | ||
| - | **[[2vyn]], [[2vyv]] - rGAPDH residues 102-432 + EcGAPDH + NAD<br /> | ||
| - | **[[2b4r]], [[2b4t]] – PfGAPDH (mutant) + NAD<br /> | ||
| - | **[[1j0x]] – GAPDH + NAD – rabbit<br /> | ||
| - | **[[1ihx]] – PvGAPDH + NAD <br /> | ||
| - | **[[1dss]], [[1szj]] - PvGAPDH NAD-binding and catalytic domains+ NAD<br /> | ||
| - | **[[1ihy]] – PvGAPDH + ADP-ribose<br /> | ||
| - | **[[1gyq]], [[1gyp]] - LmGAPDH + NAD derivative – ''Leishmania mexicana''<br /> | ||
| - | **[[1i32]], [[1i33]] – LmGAPDH + inhibitor<br /> | ||
| - | **[[1a7k]] – LmGAPDH + NAD<br /> | ||
| - | **[[1cer]], [[2g82]] - GAPDH + NAD – ''Thermus aquaticus''<br /> | ||
| - | **[[1gd1]] - GsGAPDH + NAD<br /> | ||
| - | **[[1npt]], [[1nq5]], [[1dbv]], [[2dbv]], [[3dbv]], [[4dbv]] - GsGAPDH (mutant) + NAD<br /> | ||
| - | **[[3e5r]] – OsGAPDH + NAD <br /> | ||
| - | **[[3k73]], [[3lvf]] – SaGAPDH + NAD<br /> | ||
| - | **[[3lc2]] - SaGAPDH + G3P<br /> | ||
| - | **[[3k9q]], [[3ksd]], [[3lc1]], [[3hq4]] - SaGAPDH (mutant) + NAD<br /> | ||
| - | **[[3gpd]], [[2u8f]], [[1znq]] – hGAPDH + NAD<br /> | ||
| - | **[[1gad]], [[1dc6]] - EcGAPDH + NAD<br /> | ||
| - | **[[1gae]] - EcGAPDH (mutant) + NAD<br /> | ||
| - | **[[1dc4]] – EcGAPDH + G3P<br /> | ||
| - | |||
| - | *''GAPDH ternary complex'' | ||
| - | |||
| - | **[[3id5]], [[3dmt]], [[1ml3]] – TcGAPDH + NAD + inhibitor <br /> | ||
| - | **[[1qxs]] - TcGAPDH + NAD + G3P analog<br /> | ||
| - | **[[3cif]] - CpGAPDH + NAD + G3P<br /> | ||
| - | **[[1nqa]], [[1nqo]] - GsGAPDH (mutant) + NAD + G3P<br /> | ||
| - | **[[3ksz]], [[3kv3]], [[3l4s]] - SaGAPDH (mutant) + NAD + G3P<br /> | ||
| - | |||
| - | *NADP-dependent GAPDH with cofactor NADP | ||
| - | |||
| - | **[[2dbv]], [[4dbv]] - GsGAPDH (mutant) + NADP<br /> | ||
| - | **[[2yyy]] - MjGAPDH + NADP<br /> | ||
| - | **[[2euh]] - SmGAPDH + NADP<br /> | ||
| - | **[[2id2]] - SmGAPDH (mutant) + NADP<br /> | ||
| - | **[[1cf2]] - GAPDH + NADP – ''Methanothermus fervidus''<br /> | ||
| - | **[[1jn0]], [[1rm4]], [[2pkq]], [[2pkr]] - sGAPDH + NADP<br /> | ||
| - | **[[1rm3]], [[1rm5]] - sGAPDH (mutant) + NADP<br /> | ||
| - | **[[1ky8]] - TtGAPDH + NADP – ''Thermoproteus tenax''<br /> | ||
| - | **[[3rhh]] - BhGAPDH + NADP<br /> | ||
| - | |||
| - | *''NADP-dependent GAPDH ternary complexes containing glyceraldehyde-3-phosphate (G3P)" | ||
| - | |||
| - | **[[1qi1]] - SmGAPDH + NADP + G3P<br /> | ||
| - | **[[2esd]], [[2qe0]] - SmGAPDH (mutant) + NADP + G3P<br /> | ||
| - | **[[3lc2]] – SaGAPDH-thioacyl + G3P<br /> | ||
| - | **[[1uxu]] - TtGAPDH (mutant) + NADP + AMP + G3P<br /> | ||
| - | |||
| - | *''Other NADP-dependent GAPDH ternary complexes'' | ||
| - | |||
| - | **[[1k3t]] - TcGAPDH + coumarin derivative <br /> | ||
| - | **[[1uxv]] - TtGAPDH + NADP + AMP<br /> | ||
| - | **[[1uxp]] - TtGAPDH (mutant) + NADP + ADP<br /> | ||
| - | **[[1uxq]] - TtGAPDH (mutant) + NADP + G1P<br /> | ||
| - | **[[1uxr]] - TtGAPDH (mutant) + NADP + F6P | ||
| - | |||
| - | *Uncharacterized ALDH | ||
| - | |||
| - | **[[3k9d]] – ALDH – ''Listeria monocytogenes''<br /> | ||
| - | **[[4dng]] – ALDH – ''Bacillus subtilis''<br /> | ||
| - | **[[3my7]] – ALDH – ''Vibrio parahaemolyticus''<br /> | ||
| - | **[[4qyj]] - PpALDH<br /> | ||
| - | **[[5mz5]] – PhpALDH 21 – ''Physcomitrella patens''<br /> | ||
| - | **[[5mz8]] – PhpALDH 21 + succinate<br /> | ||
| - | **[[5n5s]] – PhpALDH 21 + NADP<br /> | ||
| - | **[[6mvr]] – LoALDH 16 - ''Loktanella''<br /> | ||
| - | **[[6mvu]] – LoALDH 16 (mutant)<br /> | ||
| - | **[[6mvs]], [[6mvt]] – LoALDH 16 + NAD<br /> | ||
| - | |||
| - | *Antiquitin | ||
| - | |||
| - | **[[2jg7]] – Antiquitin – ''Acanthopagrus schlegeli'' | ||
| - | |||
| - | }} | ||
==References== | ==References== | ||
{{reflist}} | {{reflist}} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:03, 4 March 2019
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References
- ↑ Keller, Markus A.; Zander, Ulrich; Fuchs, Julian E.; Kreutz, Christoph; Watschinger, Katrin et al. (2014). A gatekeeper helix determines the substrate specificity of Sjögren–Larsson Syndrome enzyme fatty aldehyde dehydrogenase. Nature Communications vol. 5.
