This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


6cff

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6cff is ON HOLD until Mar 28 2020
+
==Stimulator of Interferon Genes Human==
-
 
+
<StructureSection load='6cff' size='340' side='right'caption='[[6cff]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-
Authors: Fernandez, D., Li, L., Ergun, S.L.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6cff]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CFF FirstGlance]. <br>
-
Description: Stimulator of Interferon Genes Human
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2BA:(2R,3R,3AS,5R,7AR,9R,10R,10AS,12R,14AR)-2,9-BIS(6-AMINO-9H-PURIN-9-YL)OCTAHYDRO-2H,7H-DIFURO[3,2-D 3,2-J][1,3,7,9,2,8]TETRAOXADIPHOSPHACYCLODODECINE-3,5,10,12-TETROL+5,12-DIOXIDE'>2BA</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cff OCA], [http://pdbe.org/6cff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cff RCSB], [http://www.ebi.ac.uk/pdbsum/6cff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cff ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN]] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Ergun, S L]]
 +
[[Category: Fernandez, D]]
[[Category: Li, L]]
[[Category: Li, L]]
-
[[Category: Fernandez, D]]
+
[[Category: 230g/232r]]
-
[[Category: Ergun, S.L]]
+
[[Category: Complex]]
 +
[[Category: Cyclic-di-amp]]
 +
[[Category: Human sting]]
 +
[[Category: Immune system]]
 +
[[Category: Tmem173]]
 +
[[Category: Wild type]]

Revision as of 11:54, 13 March 2019

Stimulator of Interferon Genes Human

PDB ID 6cff

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6cff"
Personal tools