6cnu
From Proteopedia
(Difference between revisions)
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==Crystal Structure of JzTX-V== | ==Crystal Structure of JzTX-V== | ||
| - | <StructureSection load='6cnu' size='340' side='right' | + | <StructureSection load='6cnu' size='340' side='right'caption='[[6cnu]], [[Resolution|resolution]] 1.05Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6cnu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CNU FirstGlance]. <br> | <table><tr><td colspan='2'>[[6cnu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CNU FirstGlance]. <br> | ||
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cnu OCA], [http://pdbe.org/6cnu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cnu RCSB], [http://www.ebi.ac.uk/pdbsum/6cnu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cnu ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cnu OCA], [http://pdbe.org/6cnu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cnu RCSB], [http://www.ebi.ac.uk/pdbsum/6cnu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cnu ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/JZTX5_CHIGU JZTX5_CHIGU]] Inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium channels (Nav) in rat dorsal root ganglion neurons. Highly inhibits Kv4.2/KCND2 and Kv4.3/KCND3 potassium channels and weakly inhibits Kv2.1/KCNB1 potassium channels. The toxin shifts the activation curves to more depolarized potentials. Also binds to phospholipid membranes.<ref>PMID:17150181</ref> <ref>PMID:17157888</ref> <ref>PMID:18581053</ref> <ref>PMID:20571743</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Min, X]] | [[Category: Min, X]] | ||
[[Category: Wang, Z]] | [[Category: Wang, Z]] | ||
[[Category: Inhibitor cysteine knot]] | [[Category: Inhibitor cysteine knot]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||
Revision as of 06:43, 3 July 2019
Crystal Structure of JzTX-V
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