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2vkv
From Proteopedia
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==TetR (BD) variant L17G with reverse phenotype== | ==TetR (BD) variant L17G with reverse phenotype== | ||
| - | <StructureSection load='2vkv' size='340' side='right' | + | <StructureSection load='2vkv' size='340' side='right'caption='[[2vkv]], [[Resolution|resolution]] 1.74Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2vkv]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2vkv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VKV FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TDC:5A,6-ANHYDROTETRACYCLINE'>TDC</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TDC:5A,6-ANHYDROTETRACYCLINE'>TDC</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a6i|1a6i]], [[2vke|2vke]], [[1qpi|1qpi]], [[1bjz|1bjz]], [[1du7|1du7]], [[2trt|2trt]], [[1ork|1ork]], [[1bj0|1bj0]], [[2tct|2tct]], [[1bjy|1bjy]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a6i|1a6i]], [[2vke|2vke]], [[1qpi|1qpi]], [[1bjz|1bjz]], [[1du7|1du7]], [[2trt|2trt]], [[1ork|1ork]], [[1bj0|1bj0]], [[2tct|2tct]], [[1bjy|1bjy]]</div></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vkv OCA], [https://pdbe.org/2vkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vkv RCSB], [https://www.ebi.ac.uk/pdbsum/2vkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vkv ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TETR2_ECOLX TETR2_ECOLX]] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Tetracycline repressor protein|Tetracycline repressor protein]] | + | *[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bacillus coli migula 1895]] | [[Category: Bacillus coli migula 1895]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Egerer-Sieber, C]] | [[Category: Egerer-Sieber, C]] | ||
[[Category: Henssler, E M]] | [[Category: Henssler, E M]] | ||
Revision as of 10:46, 7 July 2021
TetR (BD) variant L17G with reverse phenotype
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Categories: Bacillus coli migula 1895 | Large Structures | Egerer-Sieber, C | Henssler, E M | Hillen, W | Muller, Y A | Resch, M | Schiltz, E | Sevvana, M | Striegl, H | Anhydrotetracycline | Antibiotic resistance | Bacterial repressor | Disorder to order mechanism | Dna-binding | Helix-turn-helix motif | Magnesium | Metal-binding | Plasmid | Repressor | Reverse phenotype | Tetr | Transcription | Transcription regulation

