5zym

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Current revision (10:29, 27 March 2024) (edit) (undo)
 
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==Crystal structure of CERT START domain in complex with compound E25B==
==Crystal structure of CERT START domain in complex with compound E25B==
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<StructureSection load='5zym' size='340' side='right' caption='[[5zym]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='5zym' size='340' side='right'caption='[[5zym]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5zym]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZYM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZYM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5zym]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZYM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9M6:2-[4-[4-cyclopentyl-3-[(1~{R},2~{S})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol'>9M6</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5zyg|5zyg]], [[5zyh|5zyh]], [[5zyi|5zyi]], [[5zyj|5zyj]], [[5zyk|5zyk]], [[5zyl|5zyl]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9M6:2-[4-[4-cyclopentyl-3-[(1~{R},2~{S})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol'>9M6</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CERT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zym OCA], [https://pdbe.org/5zym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zym RCSB], [https://www.ebi.ac.uk/pdbsum/5zym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zym ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zym OCA], [http://pdbe.org/5zym PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zym RCSB], [http://www.ebi.ac.uk/pdbsum/5zym PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zym ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CERT_HUMAN CERT_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/C43BP_HUMAN C43BP_HUMAN]] Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.<ref>PMID:14685229</ref> <ref>PMID:17591919</ref> <ref>PMID:18184806</ref> <ref>PMID:20036255</ref>
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[https://www.uniprot.org/uniprot/CERT_HUMAN CERT_HUMAN] Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.<ref>PMID:14685229</ref> <ref>PMID:17591919</ref> <ref>PMID:18184806</ref> <ref>PMID:20036255</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Egawa, D]]
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[[Category: Large Structures]]
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[[Category: Hanada, K]]
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[[Category: Egawa D]]
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[[Category: Hanzawa, H]]
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[[Category: Hanada K]]
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[[Category: Kawasaki, S]]
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[[Category: Hanzawa H]]
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[[Category: Kobayashi, S]]
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[[Category: Kawasaki S]]
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[[Category: Kumagai, K]]
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[[Category: Kobayashi S]]
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[[Category: Nakao, N]]
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[[Category: Kumagai K]]
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[[Category: Sakai, S]]
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[[Category: Nakao N]]
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[[Category: Suzuki, M]]
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[[Category: Sakai S]]
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[[Category: Ueno, M]]
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[[Category: Suzuki M]]
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[[Category: Cert]]
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[[Category: Ueno M]]
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[[Category: Complex]]
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[[Category: Lipid transport]]
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[[Category: Ph]]
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[[Category: Start]]
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Current revision

Crystal structure of CERT START domain in complex with compound E25B

PDB ID 5zym

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OCA

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