1q1f

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|PDB= 1q1f |SIZE=350|CAPTION= <scene name='initialview01'>1q1f</scene>, resolution 1.50&Aring;
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|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
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|GENE= NGB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1f OCA], [http://www.ebi.ac.uk/pdbsum/1q1f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q1f RCSB]</span>
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'''Crystal structure of murine neuroglobin'''
'''Crystal structure of murine neuroglobin'''
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[[Category: Heme protein]]
[[Category: Heme protein]]
[[Category: Neuroglobin]]
[[Category: Neuroglobin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:44:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Apr 7 20:51:23 2008''
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Revision as of 02:44, 3 May 2008

Image:1q1f.jpg

Template:STRUCTURE 1q1f

Crystal structure of murine neuroglobin


Overview

Neuroglobin, a recently discovered globin predominantly expressed in neuronal tissue of vertebrates, binds small, gaseous ligands at the sixth coordination position of the heme iron. In the absence of an exogenous ligand, the distal histidine (His64) binds to the heme iron in the ferrous and ferric states. The crystal structure of murine ferric (met) neuroglobin at 1.5 A reveals interesting features relevant to the ligand binding mechanism. Only weak selectivity is observed for the two possible heme orientations, the occupancy ratio being 70:30. Two small internal cavities are present on the heme distal side, which enable the His64(E7) side chain to move out of the way upon exogenous ligand binding. Moreover, a third, huge cavity (volume approximately 290 A3) connecting both sides of the heme, is open towards the exterior and provides a potential passageway for ligands. The CD and EF corners exhibit substantial flexibility, which may assist ligands in entering the protein and accessing the active site. Based on this high-resolution structure, further structure-function studies can be planned to elucidate the role of neuroglobin in physiological responses to hypoxia.

About this Structure

1Q1F is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of murine neuroglobin: Novel pathways for ligand migration and binding., Vallone B, Nienhaus K, Brunori M, Nienhaus GU, Proteins. 2004 Jul 1;56(1):85-92. PMID:15162488 Page seeded by OCA on Sat May 3 05:44:57 2008

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