4aow
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='4aow' size='340' side='right'caption='[[4aow]], [[Resolution|resolution]] 2.45Å' scene=''> | <StructureSection load='4aow' size='340' side='right'caption='[[4aow]], [[Resolution|resolution]] 2.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4aow]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4aow]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AOW FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aow OCA], [https://pdbe.org/4aow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aow RCSB], [https://www.ebi.ac.uk/pdbsum/4aow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aow ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/GBLP_HUMAN GBLP_HUMAN]] Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. Enhances phosphorylation of HIV-1 Nef by PKCs. Promotes migration of breast carcinoma cells by binding to and activating RHOA.<ref>PMID:9584165</ref> <ref>PMID:11312657</ref> <ref>PMID:11884618</ref> <ref>PMID:12958311</ref> <ref>PMID:12589061</ref> <ref>PMID:17108144</ref> <ref>PMID:17956333</ref> <ref>PMID:17244529</ref> <ref>PMID:18258429</ref> <ref>PMID:18621736</ref> <ref>PMID:18088317</ref> <ref>PMID:19785988</ref> <ref>PMID:19423701</ref> <ref>PMID:20541605</ref> <ref>PMID:20976005</ref> <ref>PMID:20573744</ref> <ref>PMID:20499158</ref> <ref>PMID:21212275</ref> <ref>PMID:21347310</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 21: | Line 21: | ||
==See Also== | ==See Also== | ||
*[[Receptor for activated protein kinase C 1|Receptor for activated protein kinase C 1]] | *[[Receptor for activated protein kinase C 1|Receptor for activated protein kinase C 1]] | ||
| + | *[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 26: | Line 27: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Carrillo, D Ruiz]] | [[Category: Carrillo, D Ruiz]] | ||
[[Category: Chandrasekaran, R]] | [[Category: Chandrasekaran, R]] | ||
Revision as of 05:41, 25 August 2022
Crystal structure of the human Rack1 protein at a resolution of 2.45 angstrom
| |||||||||||
