Enoylpyruvate transferase
From Proteopedia
(Difference between revisions)
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MurA is composed of <scene name='55/551189/Cv/9'>catalytic domain</scene> and <scene name='55/551189/Cv/10'>C-terminal domain</scene>. The active site is located at the interface of the two domains and binds the <scene name='55/551189/Cv/11'>fosfomycin</scene> and <scene name='55/551189/Cv/12'>UDP-GlcNAc</scene>.<ref>PMID:8994972</ref> Water molecules are shown as red spheres. | MurA is composed of <scene name='55/551189/Cv/9'>catalytic domain</scene> and <scene name='55/551189/Cv/10'>C-terminal domain</scene>. The active site is located at the interface of the two domains and binds the <scene name='55/551189/Cv/11'>fosfomycin</scene> and <scene name='55/551189/Cv/12'>UDP-GlcNAc</scene>.<ref>PMID:8994972</ref> Water molecules are shown as red spheres. | ||
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| + | == 3D Structures of enoylpyruvate transferase == | ||
| + | [[Enoylpyruvate transferase 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
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**[[1uae]] – EcMurA – ''Escherichia coli''<BR /> | **[[1uae]] – EcMurA – ''Escherichia coli''<BR /> | ||
**[[2yvw]] – AaMurA – ''Aquifex aeolicus''<BR /> | **[[2yvw]] – AaMurA – ''Aquifex aeolicus''<BR /> | ||
| - | **[[3zh3]], [[3zh4]] – | + | **[[3zh3]], [[3zh4]] – SpMurA – ''Streptococcus pneumoniae''<BR /> |
**[[3r38]] – MurA – ''Listeria monocytogenes''<br /> | **[[3r38]] – MurA – ''Listeria monocytogenes''<br /> | ||
**[[3sg1]] – MurA – ''Bacillus anthracis''<br /> | **[[3sg1]] – MurA – ''Bacillus anthracis''<br /> | ||
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**[[2rl1]] – HiMurA + UNAG – Haemophilus influenzae<BR /> | **[[2rl1]] – HiMurA + UNAG – Haemophilus influenzae<BR /> | ||
**[[3kqj]] – EcMurA + UNAG <BR /> | **[[3kqj]] – EcMurA + UNAG <BR /> | ||
| + | **[[5vm7]] – EcMurA + maturation protein A2 <BR /> | ||
**[[3upk]] – EncMurA + UNAG <BR /> | **[[3upk]] – EncMurA + UNAG <BR /> | ||
**[[1ybg]] – EcMurA (mutant) + inhibitor<BR /> | **[[1ybg]] – EcMurA (mutant) + inhibitor<BR /> | ||
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**[[3v4t]], [[1ryw]] – EncMurA (mutant) + UNAG <BR /> | **[[3v4t]], [[1ryw]] – EncMurA (mutant) + UNAG <BR /> | ||
**[[5u4h]] – MurA + phosphonooxy propanoate – ''Acinetobacter baumannii''<BR /> | **[[5u4h]] – MurA + phosphonooxy propanoate – ''Acinetobacter baumannii''<BR /> | ||
| + | **[[6nkj]] – SpMurA + phosphonooxy propanoate <BR /> | ||
**[[5bq2]] – MurA + enoylpyruvyl-UNAG – ''Pseudomonas aeruginosa''<BR /> | **[[5bq2]] – MurA + enoylpyruvyl-UNAG – ''Pseudomonas aeruginosa''<BR /> | ||
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**[[2z2c]] – EcMurA + UNAG + cnicin<BR /> | **[[2z2c]] – EcMurA + UNAG + cnicin<BR /> | ||
| - | *MurA ternary complex | + | *MurA ternary complex |
**[[3su9]], [[3swa]], [[3swi]] – EncMurA (mutant) + UNAG + PEP<BR /> | **[[3su9]], [[3swa]], [[3swi]] – EncMurA (mutant) + UNAG + PEP<BR /> | ||
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**[[3swe]] – HiMurA (mutant) + UNAG + PEP<BR /> | **[[3swe]] – HiMurA (mutant) + UNAG + PEP<BR /> | ||
**[[3swg]] – AaMurA + UNAG + PEP<BR /> | **[[3swg]] – AaMurA + UNAG + PEP<BR /> | ||
| + | **[[6cn1]] – MurA + phosphonooxy propanoate + UNAG derivative – ''Pseudomonas putida''<BR /> | ||
| + | **[[5wi5]] – SpMurA + phosphonooxy propanoate + UNAG derivative<BR /> | ||
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}} | }} | ||
== References == | == References == | ||
Revision as of 06:24, 23 June 2019
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3D Structures of enoylpyruvate transferase
Updated on 23-June-2019
References
- ↑ Brown ED, Vivas EI, Walsh CT, Kolter R. MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli. J Bacteriol. 1995 Jul;177(14):4194-7. PMID:7608103
- ↑ Skarzynski T, Mistry A, Wonacott A, Hutchinson SE, Kelly VA, Duncan K. Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycin. Structure. 1996 Dec 15;4(12):1465-74. PMID:8994972
