This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Enoylpyruvate transferase
From Proteopedia
(Difference between revisions)
| Line 11: | Line 11: | ||
MurA is composed of <scene name='55/551189/Cv/9'>catalytic domain</scene> and <scene name='55/551189/Cv/10'>C-terminal domain</scene>. The active site is located at the interface of the two domains and binds the <scene name='55/551189/Cv/11'>fosfomycin</scene> and <scene name='55/551189/Cv/12'>UDP-GlcNAc</scene>.<ref>PMID:8994972</ref> Water molecules are shown as red spheres. | MurA is composed of <scene name='55/551189/Cv/9'>catalytic domain</scene> and <scene name='55/551189/Cv/10'>C-terminal domain</scene>. The active site is located at the interface of the two domains and binds the <scene name='55/551189/Cv/11'>fosfomycin</scene> and <scene name='55/551189/Cv/12'>UDP-GlcNAc</scene>.<ref>PMID:8994972</ref> Water molecules are shown as red spheres. | ||
| + | |||
| + | == 3D Structures of enoylpyruvate transferase == | ||
| + | [[Enoylpyruvate transferase 3D structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
| Line 24: | Line 28: | ||
**[[1uae]] – EcMurA – ''Escherichia coli''<BR /> | **[[1uae]] – EcMurA – ''Escherichia coli''<BR /> | ||
**[[2yvw]] – AaMurA – ''Aquifex aeolicus''<BR /> | **[[2yvw]] – AaMurA – ''Aquifex aeolicus''<BR /> | ||
| - | **[[3zh3]], [[3zh4]] – | + | **[[3zh3]], [[3zh4]] – SpMurA – ''Streptococcus pneumoniae''<BR /> |
**[[3r38]] – MurA – ''Listeria monocytogenes''<br /> | **[[3r38]] – MurA – ''Listeria monocytogenes''<br /> | ||
**[[3sg1]] – MurA – ''Bacillus anthracis''<br /> | **[[3sg1]] – MurA – ''Bacillus anthracis''<br /> | ||
| Line 42: | Line 46: | ||
**[[2rl1]] – HiMurA + UNAG – Haemophilus influenzae<BR /> | **[[2rl1]] – HiMurA + UNAG – Haemophilus influenzae<BR /> | ||
**[[3kqj]] – EcMurA + UNAG <BR /> | **[[3kqj]] – EcMurA + UNAG <BR /> | ||
| + | **[[5vm7]] – EcMurA + maturation protein A2 <BR /> | ||
**[[3upk]] – EncMurA + UNAG <BR /> | **[[3upk]] – EncMurA + UNAG <BR /> | ||
**[[1ybg]] – EcMurA (mutant) + inhibitor<BR /> | **[[1ybg]] – EcMurA (mutant) + inhibitor<BR /> | ||
| Line 48: | Line 53: | ||
**[[3v4t]], [[1ryw]] – EncMurA (mutant) + UNAG <BR /> | **[[3v4t]], [[1ryw]] – EncMurA (mutant) + UNAG <BR /> | ||
**[[5u4h]] – MurA + phosphonooxy propanoate – ''Acinetobacter baumannii''<BR /> | **[[5u4h]] – MurA + phosphonooxy propanoate – ''Acinetobacter baumannii''<BR /> | ||
| + | **[[6nkj]] – SpMurA + phosphonooxy propanoate <BR /> | ||
**[[5bq2]] – MurA + enoylpyruvyl-UNAG – ''Pseudomonas aeruginosa''<BR /> | **[[5bq2]] – MurA + enoylpyruvyl-UNAG – ''Pseudomonas aeruginosa''<BR /> | ||
| Line 59: | Line 65: | ||
**[[2z2c]] – EcMurA + UNAG + cnicin<BR /> | **[[2z2c]] – EcMurA + UNAG + cnicin<BR /> | ||
| - | *MurA ternary complex | + | *MurA ternary complex |
**[[3su9]], [[3swa]], [[3swi]] – EncMurA (mutant) + UNAG + PEP<BR /> | **[[3su9]], [[3swa]], [[3swi]] – EncMurA (mutant) + UNAG + PEP<BR /> | ||
| Line 65: | Line 71: | ||
**[[3swe]] – HiMurA (mutant) + UNAG + PEP<BR /> | **[[3swe]] – HiMurA (mutant) + UNAG + PEP<BR /> | ||
**[[3swg]] – AaMurA + UNAG + PEP<BR /> | **[[3swg]] – AaMurA + UNAG + PEP<BR /> | ||
| + | **[[6cn1]] – MurA + phosphonooxy propanoate + UNAG derivative – ''Pseudomonas putida''<BR /> | ||
| + | **[[5wi5]] – SpMurA + phosphonooxy propanoate + UNAG derivative<BR /> | ||
| + | |||
}} | }} | ||
== References == | == References == | ||
Revision as of 06:24, 23 June 2019
| |||||||||||
3D Structures of enoylpyruvate transferase
Updated on 23-June-2019
References
- ↑ Brown ED, Vivas EI, Walsh CT, Kolter R. MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli. J Bacteriol. 1995 Jul;177(14):4194-7. PMID:7608103
- ↑ Skarzynski T, Mistry A, Wonacott A, Hutchinson SE, Kelly VA, Duncan K. Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycin. Structure. 1996 Dec 15;4(12):1465-74. PMID:8994972
