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6jjp

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'''Unreleased structure'''
 
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The entry 6jjp is ON HOLD until Paper Publication
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==Crystal structure of Fab of a PD-1 monoclonal antibody MW11-h317 in complex with PD-1==
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<StructureSection load='6jjp' size='340' side='right'caption='[[6jjp]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6jjp]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JJP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JJP FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jjp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jjp OCA], [http://pdbe.org/6jjp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jjp RCSB], [http://www.ebi.ac.uk/pdbsum/6jjp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jjp ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN]] Systemic lupus erythematosus;Multiple sclerosis. Systemic lupus erythematosus 2 (SLEB2) [MIM:[http://omim.org/entry/605218 605218]]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.<ref>PMID:12402038</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.<ref>PMID:21276005</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Jiao, S]]
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[[Category: Wang, J]]
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[[Category: Wang, M]]
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[[Category: Wang, R]]
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[[Category: Wang, S]]
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[[Category: Zhang, J]]
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[[Category: Zhang, M]]
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[[Category: Cancer treatment]]
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[[Category: Immune system]]
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[[Category: Monoclonal antibody]]
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[[Category: Pd-1]]

Revision as of 09:03, 30 October 2019

Crystal structure of Fab of a PD-1 monoclonal antibody MW11-h317 in complex with PD-1

PDB ID 6jjp

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