6jkb

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'''Unreleased structure'''
 
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The entry 6jkb is ON HOLD until Paper Publication
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==Crystal structure of metallo-beta-lactamse, NDM-1, in complex with hydrolyzed ampicillin==
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<StructureSection load='6jkb' size='340' side='right'caption='[[6jkb]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
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Authors: Kamo, T., Kuroda, K., Kondo, S., Hayashi, U., Fudo, S., Nukaga, M., Hoshino, T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6jkb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JKB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JKB FirstGlance]. <br>
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Description: Crystal structure of metallo-beta-lactamse, NDM-1, in complex with hydrolyzed ampicillin
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=ZZ7:(2R,4S)-2-[(R)-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}(CARBOXY)METHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>ZZ7</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jkb OCA], [http://pdbe.org/6jkb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jkb RCSB], [http://www.ebi.ac.uk/pdbsum/6jkb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jkb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
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__TOC__
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</StructureSection>
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[[Category: Beta-lactamase]]
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[[Category: Large Structures]]
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[[Category: Fudo, S]]
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[[Category: Hayashi, U]]
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[[Category: Hoshino, T]]
[[Category: Kamo, T]]
[[Category: Kamo, T]]
[[Category: Kondo, S]]
[[Category: Kondo, S]]
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[[Category: Kuroda, K]]
[[Category: Nukaga, M]]
[[Category: Nukaga, M]]
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[[Category: Hoshino, T]]
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[[Category: Antibiotic]]
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[[Category: Kuroda, K]]
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[[Category: Hydrolase]]
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[[Category: Hayashi, U]]
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[[Category: Fudo, S]]
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Revision as of 10:02, 27 March 2020

Crystal structure of metallo-beta-lactamse, NDM-1, in complex with hydrolyzed ampicillin

PDB ID 6jkb

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OCA

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