6jly
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==eIF2a - eIF2B complex== | |
| - | + | <StructureSection load='6jly' size='340' side='right'caption='[[6jly]], [[Resolution|resolution]] 3.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6jly]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JLY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JLY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jly OCA], [http://pdbe.org/6jly PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jly RCSB], [http://www.ebi.ac.uk/pdbsum/6jly PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jly ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IF2A_YEAST IF2A_YEAST]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. [[http://www.uniprot.org/uniprot/EI2BD_SCHPO EI2BD_SCHPO]] Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. [[http://www.uniprot.org/uniprot/EI2BA_SCHPO EI2BA_SCHPO]] Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. [[http://www.uniprot.org/uniprot/EI2BG_SCHPO EI2BG_SCHPO]] Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. [[http://www.uniprot.org/uniprot/EI2BB_SCHPO EI2BB_SCHPO]] Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. [[http://www.uniprot.org/uniprot/EI2BE_SCHPO EI2BE_SCHPO]] Subunit of the guanine nucleotide exchange factor for eIF-2. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ito, T]] | ||
| + | [[Category: Kashiwagi, K]] | ||
| + | [[Category: Translation]] | ||
| + | [[Category: Translation initiation]] | ||
Revision as of 08:52, 1 May 2019
eIF2a - eIF2B complex
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