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6qvo

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m (Protected "6qvo" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6qvo is ON HOLD
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==Crystal structure of human MTH1 in complex with N6-methyl-dAMP==
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<StructureSection load='6qvo' size='340' side='right'caption='[[6qvo]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6qvo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QVO FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MA:N6-METHYL-DEOXY-ADENOSINE-5-MONOPHOSPHATE'>6MA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qvo OCA], [http://pdbe.org/6qvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qvo RCSB], [http://www.ebi.ac.uk/pdbsum/6qvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qvo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Berglund, U Warpman]]
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[[Category: Brautigam, L]]
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[[Category: Helleday, T]]
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[[Category: Jemth, A S]]
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[[Category: Sarno, A]]
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[[Category: Scaletti, E]]
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[[Category: Stenmark, P]]
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[[Category: Vallin, K S]]
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[[Category: Hydrolase]]

Revision as of 09:48, 18 March 2020

Crystal structure of human MTH1 in complex with N6-methyl-dAMP

PDB ID 6qvo

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