6qwv

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m (Protected "6qwv" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6qwv is ON HOLD until Paper Publication
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==SARM1 SAM1-2 domains==
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<StructureSection load='6qwv' size='340' side='right'caption='[[6qwv]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
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Authors: Sporny, M., Isupov, N.M., Opatowsky, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6qwv]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QWV FirstGlance]. <br>
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Description: signaling protein
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qwv OCA], [http://pdbe.org/6qwv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qwv RCSB], [http://www.ebi.ac.uk/pdbsum/6qwv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qwv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SARM1_HUMAN SARM1_HUMAN]] Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.<ref>PMID:15123841</ref> <ref>PMID:16964262</ref> <ref>PMID:16985498</ref> <ref>PMID:20306472</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Isupov, N M]]
[[Category: Opatowsky, Y]]
[[Category: Opatowsky, Y]]
[[Category: Sporny, M]]
[[Category: Sporny, M]]
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[[Category: Isupov, N.M]]
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[[Category: Apoptosis]]

Revision as of 06:02, 3 July 2019

SARM1 SAM1-2 domains

PDB ID 6qwv

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