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| - | | + | #REDIRECT [[6o98]] This PDB entry is obsolete and replaced by 6o98 |
| - | ==Crystal structure of RAR-related orphan receptor C (NHIS- RORgt(244-487)-L6-SRC1(678-692)) in complex with a phenyl (3-phenylpyrrolidin-3-yl)sulfone inhibitor==
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| - | <StructureSection load='6nxh' size='340' side='right'caption='[[6nxh]], [[Resolution|resolution]] 1.90Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[6nxh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NXH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NXH FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=L8A:1-(4-{(3R)-3-[(4-fluorophenyl)sulfonyl]-3-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]pyrrolidine-1-carbonyl}piperazin-1-yl)ethan-1-one'>L8A</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6nx1|6nx1]]</td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nxh OCA], [http://pdbe.org/6nxh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nxh RCSB], [http://www.ebi.ac.uk/pdbsum/6nxh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nxh ProSAT]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Large Structures]]
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| - | [[Category: Sack, J]]
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| - | [[Category: Inverse agonist]]
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| - | [[Category: Ligand-binding domain]]
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| - | [[Category: Nuclear hormone receptor]]
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| - | [[Category: Rorgt]]
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| - | [[Category: Transcription-inhibitor complex]]
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