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4bx9

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<StructureSection load='4bx9' size='340' side='right'caption='[[4bx9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4bx9' size='340' side='right'caption='[[4bx9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bx9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BX9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BX9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bx9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BX9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BX9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bx8|4bx8]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bx9 OCA], [https://pdbe.org/4bx9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bx9 RCSB], [https://www.ebi.ac.uk/pdbsum/4bx9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bx9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bx9 OCA], [http://pdbe.org/4bx9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bx9 RCSB], [http://www.ebi.ac.uk/pdbsum/4bx9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bx9 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VP33A_HUMAN VP33A_HUMAN]] May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes (By similarity). [[http://www.uniprot.org/uniprot/VPS16_HUMAN VPS16_HUMAN]] May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.
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[[https://www.uniprot.org/uniprot/VP33A_HUMAN VP33A_HUMAN]] May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The multisubunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is required for late endosome-lysosome and autophagosome-lysosome fusion in mammals. We have determined the crystal structure of the human HOPS subunit Vps33A, confirming its identity as a Sec1/Munc18 family member. We show that HOPS subunit Vps16 recruits Vps33A to the human HOPS complex and that residues 642-736 are necessary and sufficient for this interaction, and we present the crystal structure of Vps33A in complex with Vps16(642-736). Mutations at the binding interface disrupt the Vps33A-Vps16 interaction both in vitro and in cells, preventing recruitment of Vps33A to the HOPS complex. The Vps33A-Vps16 complex provides a structural framework for studying the association between Sec1/Munc18 proteins and tethering complexes.
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Structural basis of Vps33A recruitment to the human HOPS complex by Vps16.,Graham SC, Wartosch L, Gray SR, Scourfield EJ, Deane JE, Luzio JP, Owen DJ Proc Natl Acad Sci U S A. 2013 Jul 30. PMID:23901104<ref>PMID:23901104</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4bx9" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[Vacuolar protein sorting-associated protein|Vacuolar protein sorting-associated protein]]
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*[[Vacuolar protein sorting-associated protein 3D structures|Vacuolar protein sorting-associated protein 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Deane, J E]]
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[[Category: Deane JE]]
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[[Category: Graham, S C]]
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[[Category: Graham SC]]
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[[Category: Gray, S R]]
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[[Category: Gray SR]]
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[[Category: Luzio, J P]]
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[[Category: Luzio JP]]
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[[Category: Owen, D J]]
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[[Category: Owen DJ]]
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[[Category: Scourfield, E J]]
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[[Category: Scourfield EJ]]
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[[Category: Wartosch, L]]
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[[Category: Wartosch L]]
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[[Category: Hop]]
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[[Category: Membrane trafficking]]
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[[Category: Protein transport]]
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[[Category: Sec1/munc18 protein]]
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[[Category: Tethering]]
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Revision as of 17:14, 7 September 2022

Human Vps33A in complex with a fragment of human Vps16

PDB ID 4bx9

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