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5wdd

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Revision as of 09:46, 9 September 2020

Crystal structure of chicken BOK

Structural highlights

5wdd is a 2 chain structure with sequence from Chick. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:	BOK (CHICK)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BOK_CHICK] May play a role in apoptosis.[UniProtKB:O35425]

Publication Abstract from PubMed

Intrinsic apoptosis, reliant on BAX and BAK, has been postulated to be fundamental for morphogenesis, but its precise contribution to this process has not been fully explored in mammals. Our structural analysis of BOK suggests close resemblance to BAX and BAK structures. Notably, Bok(-/-)Bax(-/-)Bak(-/-) animals exhibited more severe defects and died earlier than Bax(-/-)Bak(-/-) mice, implying that BOK has overlapping roles with BAX and BAK during developmental cell death. By analyzing Bok(-/-)Bax(-/-)Bak(-/-) triple-knockout mice whose cells are incapable of undergoing intrinsic apoptosis, we identified tissues that formed well without this process. We provide evidence that necroptosis, pyroptosis, or autophagy does not substantially substitute for the loss of apoptosis. Albeit very rare, unexpected attainment of adult Bok(-/-)Bax(-/-)Bak(-/-) mice suggests that morphogenesis can proceed entirely without apoptosis mediated by these proteins and possibly without cell death in general.

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK.,Ke FFS, Vanyai HK, Cowan AD, Delbridge ARD, Whitehead L, Grabow S, Czabotar PE, Voss AK, Strasser A Cell. 2018 May 17;173(5):1217-1230.e17. doi: 10.1016/j.cell.2018.04.036. PMID:29775594^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Ke FFS, Vanyai HK, Cowan AD, Delbridge ARD, Whitehead L, Grabow S, Czabotar PE, Voss AK, Strasser A. Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK. Cell. 2018 May 17;173(5):1217-1230.e17. doi: 10.1016/j.cell.2018.04.036. PMID:29775594 doi:http://dx.doi.org/10.1016/j.cell.2018.04.036

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5wdd"

@@ Line 3: / Line 3: @@
 <StructureSection load='5wdd' size='340' side='right'caption='[[5wdd]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5wdd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WDD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WDD FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5wdd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WDD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5WDD FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BOK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wdd OCA], [http://pdbe.org/5wdd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wdd RCSB], [http://www.ebi.ac.uk/pdbsum/5wdd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wdd ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5wdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wdd OCA], [http://pdbe.org/5wdd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wdd RCSB], [http://www.ebi.ac.uk/pdbsum/5wdd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wdd ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 26: / Line 26: @@
 [[Category: Large Structures]]
 [[Category: Colman, P M]]
-[[Category: Cowan, A C]]
+[[Category: Cowan, A D]]
 [[Category: Czabotar, P E]]
 [[Category: Apoptosis]]

5wdd

From Proteopedia

Revision as of 09:46, 9 September 2020

Crystal structure of chicken BOK

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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