4bza

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<StructureSection load='4bza' size='340' side='right'caption='[[4bza]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
<StructureSection load='4bza' size='340' side='right'caption='[[4bza]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bza]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecobd Ecobd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BZA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bza]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BZA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c00|4c00]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bza OCA], [https://pdbe.org/4bza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bza RCSB], [https://www.ebi.ac.uk/pdbsum/4bza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bza ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bza OCA], [http://pdbe.org/4bza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bza RCSB], [http://www.ebi.ac.uk/pdbsum/4bza PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bza ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TAMA_ECOLI TAMA_ECOLI]] Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane. Has anion selective channel-forming ability, but the physiological relevance of this activity is unclear.<ref>PMID:22466966</ref>
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[[https://www.uniprot.org/uniprot/TAMA_ECOLI TAMA_ECOLI]] Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane. Has anion selective channel-forming ability, but the physiological relevance of this activity is unclear.<ref>PMID:22466966</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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TamA is an Escherichia coli Omp85 protein involved in autotransporter biogenesis. It comprises a 16-stranded transmembrane beta-barrel and three POTRA domains. The 2.3-A crystal structure reveals that the TamA barrel is closed at the extracellular face by a conserved lid loop. The C-terminal beta-strand of the barrel forms an unusual inward kink, which weakens the lateral barrel wall and creates a gate for substrate access to the lipid bilayer.
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The structural basis of autotransporter translocation by TamA.,Gruss F, Zahringer F, Jakob RP, Burmann BM, Hiller S, Maier T Nat Struct Mol Biol. 2013 Sep 22. doi: 10.1038/nsmb.2689. PMID:24056943<ref>PMID:24056943</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4bza" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecobd]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Burmann, B M]]
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[[Category: Burmann BM]]
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[[Category: Gruss, F]]
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[[Category: Gruss F]]
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[[Category: Hiller, S]]
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[[Category: Hiller S]]
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[[Category: Jakob, R P]]
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[[Category: Jakob RP]]
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[[Category: Maier, T]]
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[[Category: Maier T]]
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[[Category: Zaehringer, F]]
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[[Category: Zaehringer F]]
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[[Category: Autotransporter biogenesis]]
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[[Category: Outer membrane protein]]
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[[Category: Polypeptide transport-associated]]
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[[Category: Transport protein]]
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Revision as of 17:17, 7 September 2022

Crystal structure of TamA POTRA domains 1-3 from E. coli

PDB ID 4bza

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