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4bw0

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<StructureSection load='4bw0' size='340' side='right'caption='[[4bw0]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
<StructureSection load='4bw0' size='340' side='right'caption='[[4bw0]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bw0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcfl Arcfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BW0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BW0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bw0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus] and [https://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BW0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BW0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c40|4c40]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bw0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bw0 OCA], [https://pdbe.org/4bw0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bw0 RCSB], [https://www.ebi.ac.uk/pdbsum/4bw0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bw0 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bw0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bw0 OCA], [http://pdbe.org/4bw0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bw0 RCSB], [http://www.ebi.ac.uk/pdbsum/4bw0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bw0 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RL7A_ARCFU RL7A_ARCFU]] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA and box C/D sRNAs.<ref>PMID:12560482</ref>
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[[https://www.uniprot.org/uniprot/RL7A_ARCFU RL7A_ARCFU]] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA and box C/D sRNAs.<ref>PMID:12560482</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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L7Ae is a member of a protein family that binds kink-turns (k-turns) in many functional RNA species. We have solved the X-ray crystal structure of the near-consensus sequence Kt-7 of Haloarcula marismortui bound by Archaeoglobus fulgidus L7Ae at 2.3-A resolution. We also present a structure of Kt-7 in the absence of bound protein at 2.2-A resolution. As a result, we can describe a general mode of recognition of k-turn structure by the L7Ae family proteins. The protein makes interactions in the widened major groove on the outer face of the k-turn. Two regions of the protein are involved. One is an alpha-helix that enters the major groove of the NC helix, making both nonspecific backbone interactions and specific interactions with the guanine nucleobases of the conserved G*A pairs. A hydrophobic loop makes close contact with the L1 and L2 bases, and a glutamate side chain hydrogen bonds with L1. Taken together, these interactions are highly selective for the structure of the k-turn and suggest how conformational selection of the folded k-turn occurs.
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The molecular recognition of kink-turn structure by the L7Ae class of proteins.,Huang L, Lilley DM RNA. 2013 Oct 22. PMID:24149842<ref>PMID:24149842</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4bw0" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arcfl]]
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[[Category: Archaeoglobus fulgidus]]
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[[Category: Haloarcula marismortui]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Huang, L]]
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[[Category: Huang L]]
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[[Category: Lilley, D M.J]]
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[[Category: Lilley DMJ]]
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[[Category: Rna-rna binding protein complex]]
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Revision as of 17:11, 7 September 2022

The molecular recognition of kink turn structure by the L7Ae class of proteins

PDB ID 4bw0

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