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4by0
From Proteopedia
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<StructureSection load='4by0' size='340' side='right'caption='[[4by0]], [[Resolution|resolution]] 3.10Å' scene=''> | <StructureSection load='4by0' size='340' side='right'caption='[[4by0]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4by0]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4by0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BY0 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5PS:(R)-N-(3-(1H-INDOL-3-YL)-1-OXO-1-(PYRIDIN-4-YLAMINO)PROPAN-2-YL)-3,3-DIFLUORO-(1,1-BIPHENYL)-4-CARBOXAMIDE'>5PS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5PS:(R)-N-(3-(1H-INDOL-3-YL)-1-OXO-1-(PYRIDIN-4-YLAMINO)PROPAN-2-YL)-3,3-DIFLUORO-(1,1-BIPHENYL)-4-CARBOXAMIDE'>5PS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4by0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by0 OCA], [https://pdbe.org/4by0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4by0 RCSB], [https://www.ebi.ac.uk/pdbsum/4by0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4by0 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CP51_TRYCC CP51_TRYCC]] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.<ref>PMID:16321980</ref> [UniProtKB:P0A512] |
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== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Trypanosoma cruzi]] |
| - | + | [[Category: Calvet CM]] | |
| - | [[Category: Calvet | + | [[Category: Cameron MD]] |
| - | [[Category: Cameron | + | [[Category: Choi JY]] |
| - | [[Category: Choi | + | [[Category: Gunatilleke SS]] |
| - | [[Category: Gunatilleke | + | [[Category: McKerrow JH]] |
| - | [[Category: McKerrow | + | [[Category: Podust LM]] |
| - | [[Category: Podust | + | [[Category: Roush WR]] |
| - | [[Category: Roush | + | [[Category: Vierira DF]] |
| - | [[Category: Vierira | + | |
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Revision as of 17:15, 7 September 2022
Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-3,3'- difluoro-(1,1'-biphenyl)-4-carboxamide
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