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4bwx
From Proteopedia
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<StructureSection load='4bwx' size='340' side='right'caption='[[4bwx]], [[Resolution|resolution]] 2.85Å' scene=''> | <StructureSection load='4bwx' size='340' side='right'caption='[[4bwx]], [[Resolution|resolution]] 2.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4bwx]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4bwx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BWX FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bwx OCA], [https://pdbe.org/4bwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bwx RCSB], [https://www.ebi.ac.uk/pdbsum/4bwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bwx ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/PAN3_NEUCR PAN3_NEUCR]] Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex involved in cytoplasmic mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by polyadenylate-binding protein pab-1. Deadenylation of the 3'-tail to a length that is too short to bind pab-1 induces mRNA decay. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. pan-3 acts as a positive regulator for PAN activity, recruiting pan-2 to mRNA via its interaction with pab-1 (By similarity). |
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==See Also== | ==See Also== | ||
| - | *[[Ribonuclease|Ribonuclease]] | + | *[[Ribonuclease 3D structures|Ribonuclease 3D structures]] |
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Chrysonilia crassa]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Boland | + | [[Category: Neurospora crassa]] |
| - | [[Category: Christie | + | [[Category: Boland A]] |
| - | [[Category: Huntzinger | + | [[Category: Christie M]] |
| - | [[Category: Izaurralde | + | [[Category: Huntzinger E]] |
| - | [[Category: Weichenrieder | + | [[Category: Izaurralde E]] |
| - | + | [[Category: Weichenrieder O]] | |
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Revision as of 17:14, 7 September 2022
Structure of Neurospora crassa PAN3 pseudokinase mutant
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