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4bz4

From Proteopedia

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Current revision (17:17, 7 September 2022) (edit) (undo)
 
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<StructureSection load='4bz4' size='340' side='right'caption='[[4bz4]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='4bz4' size='340' side='right'caption='[[4bz4]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bz4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylomicrobium_album_bg8 Methylomicrobium album bg8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BZ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BZ4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bz4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylomicrobium_album_BG8 Methylomicrobium album BG8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BZ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BZ4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene>, <scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bz4 OCA], [https://pdbe.org/4bz4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bz4 RCSB], [https://www.ebi.ac.uk/pdbsum/4bz4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bz4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bz4 OCA], [http://pdbe.org/4bz4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bz4 RCSB], [http://www.ebi.ac.uk/pdbsum/4bz4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bz4 ProSAT]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[[https://www.uniprot.org/uniprot/H8GPE3_METAL H8GPE3_METAL]]
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CorA is a copper repressible protein previously identified in the methanotrophic bacterium Methylomicrobium album BG8. In this work, we demonstrate that CorA is located on the cell surface and binds one copper ion per protein molecule, which, based on X-ray Absorption Near Edge Structure analysis, is in the reduced state (Cu(I)). The structure of endogenously expressed CorA was solved using X-ray crystallography. The 1.6 A three-dimensional structure confirmed the binding of copper and revealed that the copper atom was coordinated in a mononuclear binding site defined by two histidines, one water molecule, and the tryptophan metabolite, kynurenine. This arrangement of the copper-binding site is similar to that of its homologous protein MopE* from Metylococcus capsulatus Bath, confirming the importance of kynurenine for copper binding in these proteins. Our findings show that CorA has an overall fold similar to MopE, including the unique copper(I)-binding site and most of the secondary structure elements. We suggest that CorA plays a role in the M. album BG8 copper acquisition.
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CorA Is a Copper Repressible Surface-Associated Copper(I)-Binding Protein Produced in Methylomicrobium album BG8.,Johnson KA, Ve T, Larsen O, Pedersen RB, Lillehaug JR, Jensen HB, Helland R, Karlsen OA PLoS One. 2014 Feb 3;9(2):e87750. doi: 10.1371/journal.pone.0087750. eCollection , 2014. PMID:24498370<ref>PMID:24498370</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4bz4" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Methylomicrobium album bg8]]
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[[Category: Methylomicrobium album BG8]]
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[[Category: Helland, R]]
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[[Category: Helland R]]
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[[Category: Jensen, H B]]
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[[Category: Jensen HB]]
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[[Category: Johnson, K A]]
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[[Category: Johnson KA]]
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[[Category: Karlsen, O A]]
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[[Category: Karlsen OA]]
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[[Category: Lillehaug, J R]]
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[[Category: Lillehaug JR]]
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[[Category: Pedersen, R B]]
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[[Category: Pedersen RB]]
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[[Category: Ve, T]]
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[[Category: Ve T]]
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[[Category: Copper acquisition]]
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[[Category: Copper-binding protein]]
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[[Category: Methanotroph]]
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Current revision

CorA is a surface-associated copper-binding protein important in Methylomicrobium album BG8 copper acquisition

PDB ID 4bz4

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