4bum

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<StructureSection load='4bum' size='340' side='right'caption='[[4bum]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='4bum' size='340' side='right'caption='[[4bum]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bum]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BUM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bum]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BUM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bum OCA], [http://pdbe.org/4bum PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bum RCSB], [http://www.ebi.ac.uk/pdbsum/4bum PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bum ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bum OCA], [https://pdbe.org/4bum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bum RCSB], [https://www.ebi.ac.uk/pdbsum/4bum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bum ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[[https://www.uniprot.org/uniprot/Q8AWD0_DANRE Q8AWD0_DANRE]]
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In recent years, there has been a vast increase in structural and functional understanding of VDAC1, but VDAC2 and 3 have been understudied despite having many unique phenotypes. One reason for the paucity of structural and biochemical characterization of the 2 and 3 isoforms stems from the inability of obtaining purified, functional protein. Here we demonstrate the expression, isolation, and basic characterization of zebrafish (zf) VDAC2. Further, we resolved the structure of zfVDAC2 at 2.8A resolution revealing a crystallographic dimer. The dimer orientation was confirmed in solution by double electron-electron resonance spectroscopy and by cross-linking experiments disclosing a dimer population of ~20% in LDAO detergent micelles and ~40% in lipidic bicelles with the presence of some higher order oligomers in the latter. The present study allows for a more accurate structural comparison between VDAC2 and its better-studied counterpart VDAC1.
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High-Resolution Structure and Double Electron-Electron Resonance of the Zebrafish Voltage Dependent Anion Channel 2 Reveal an Oligomeric Population.,Schredelseker J, Paz A, Lopez CJ, Altenbach C, Leung CS, Drexler MK, Chen JN, Hubbell WL, Abramson J J Biol Chem. 2014 Mar 13. PMID:24627492<ref>PMID:24627492</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4bum" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[Ion channels|Ion channels]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Brachidanio rerio]]
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[[Category: Danio rerio]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Abramson, J]]
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[[Category: Abramson J]]
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[[Category: Paz, A]]
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[[Category: Paz A]]
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[[Category: Schredelseker, J]]
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[[Category: Schredelseker J]]
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[[Category: Detergent]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Mitochondria]]
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[[Category: Porin]]
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[[Category: Recombinant]]
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Revision as of 17:08, 7 September 2022

Crystal structure of the Voltage Dependant Anion Channel 2 from zebrafish.

PDB ID 4bum

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